Practical implementation of automated insulin delivery systems in 2025: A French position statement update.

The advent of automated insulin delivery (AID) systems in 2020 marked a disruptive event in managing type 1 diabetes, benefiting children and adults alike. By 2024, advances in real-world data and research motivated an update to the French consensus on AID systems to expand accessibility, refine guidelines, and optimize patient follow-up. AID systems have consistently improved glycemic control by reducing HbA1c, increasing time-in-range (TIR), and minimizing hypoglycemia, with significant benefits even for specific populations such as individuals with poor glycemic control, brittle diabetes, children, very young children, pregnant women, those with insulin resistance or gastroparesis, or after bariatric surgery.

Elucidating diagnostic efficacy and safety of the procedure: cryobiopsy of endobronchial lesions with a flexible bronchoscope.

When compared to conventional forceps biopsy, the use of a flexible cryoprobe allows for the sampling of endobronchial lesions, yielding well-preserved, circumferential, and substantial specimens, resulting in a higher diagnostic yield, as demonstrated in multiple studies. We evaluated the utility of cryobiopsy in the diagnosis of endobronchial lesions, as well as its safety profile in this study. This retrospective study included 200 patients who underwent cryobiopsy for bronchoscopically visible endobronchial lesions between March 2016 and July 2022.

MPPT of solar PV systems using PSO memetic algorithm considering the effect of change in tilt angle.

Tracking the peak power output of solar photovoltaic modules poses a significant challenge in contemporary times, that too under variable climatic conditions. Despite the availability of various Maximum Power Point Tracking (MPPT) methods, each method carries its own set of limitations. Many of these constraints can be effectively addressed by leveraging a suitable metaheuristic algorithm.

Machine Learning Approaches for Blood Pressure Classification from Photoplethysmogram: A Comparative Analysis.

The cuffless estimation of blood pressure (BP) has become a prominent area of research in recent years fueled by its potential clinical implications and the growing interest from the wearable device industry. It has been accelerated by the emergence of learning-based models. Most use multiple pulse signals such as ECG, PPG, etc.

Heart-Carotid Pulse Wave Velocity for Non-invasive Vascular Stiffness Assessment: A Feasibility Study.

Carotid-femoral pulse wave velocity (cfPWV) is one of the established markers of aortic arterial stiffness with proven predictive capability for adverse cardiovascular events. Despite a large body of clinical evidence, cfPWV is not routinely assessed in clinical practice nor used for ambulatory or self-monitoring, as it requires access to the femoral site, which leads to poor subject compliance for the assessment. Heart-carotid PWV (hcPWV) is a potential alternative for measuring aortic arterial stiffness in settings where cf-PWV is challenging to measure.

mSTEP: An Automated Algorithm for Blood Pressure Measurement from Korotkoff Sounds.

Accurate blood pressure measurement is crucial for effective health monitoring, with oscillometric and auscultation methods being commonly employed. However, oscillometric measurements are population-dependent, and manual auscultation relies heavily on operator skill. This study introduces the modulated Short-Time Energy and finding the peaks (mSTEP) algorithm, designed to automate the tracking of systolic blood pressure (SBP) and diastolic blood pressure (DBP) from auscultatory signals, aiming to provide accurate BP measurements.

A Feasibility Study on the Response of Vascular Impedance to Reactive Hyperemia.

Endothelium-dependent vascular reactivity has been recommended as a reliable indicator of vessel health. Ultrasound-based assessment of diameter response to shear stress measured as the proportion of brachial dilatation caused by reactive hyperemia (RH), is the gold standard for evaluating endothelial reactivity. However, the conventional approach does not account for the transient increase in blood flow and subsequent change in the transmural pressure that stimulates the endothelial cells to dilate the artery.

Jugular Venous Pulse Waveform Acquisition using Contact Piezo Sensor: A Pilot Study.

The jugular venous pulse (JVP) is an important signal for detecting cardiovascular abnormalities pertaining to the right atrium. The gold standard technique of central venous line catheterization is invasive, risky, and demands expertise and hence performed only in critical care settings. Non-invasive approaches such as ultrasound and photoplethysmography are used for JVP measurement but are limited by usability issues related to the operator's expertise.

Characterizing the Effect of Hold-Down Pressure for Local and Regional Stiffness Markers.

Vascular aging occurs due to pathologies and old age. Early detection of stiffness markers and arterial geometry parameters in the carotid artery serves as an essential indicator for the progression of vascular aging. The assessment of stiffness markers is typically conducted using ultrasound and tonometer-based devices.

Assessing angiographic results of saline autotransfusion and thrombus aspiration in STEMI patients.

Background: Effective myocardial reperfusion in ST-Elevation Myocardial Infarction (STEMI) remains challenging despite advancements in primary percutaneous coronary intervention (PCI). This study evaluates the impact of thrombus aspiration (TA) and saline autotransfusion (SAT) compared to standard PCI (NOTA) on coronary flow dynamics and myocardial perfusion.

Research Design And Method: This prospective cohort study enrolled 157 STEMI patients who underwent primary PCI.

Posterior scalp block with bupivacaine and dexmedetomidine for pain management in posterior fossa surgeries: a prospective, double blind randomized controlled trial.

Background: Pain management in posterior fossa surgeries poses significant challenges, with opioid-based approaches causing unwanted side effects. This study evaluates the efficacy of posterior scalp block using bupivacaine and dexmedetomidine compared to skin infiltration for managing perioperative pain.

Methods: In this prospective, double-blind, randomized controlled trial, 34 adult patients undergoing elective posterior fossa surgeries were equally assigned to either posterior scalp block or skin infiltration groups.

Investigation of physical, structural, optical, and luminescence properties of nickel oxide doped alkali zinco-borate glasses.

Glasses having the stoichiometry ratio [(70-x) BO-10NaO-20ZnO-xNiO] where 0.0 ≤ x < 0.3 mol% were synthesized using a melt quenching technique.

Plant-derived terpenoids modulating cancer cell metabolism and cross-linked signaling pathways: an updated reviews.

Cancer is a critical health issue that remains a predominant cause of mortality globally. It is a complex disease that may effectively regulate many signaling pathways and modify the metabolism of the body to evade the immune system. Understanding neoplastic metabolic reprogramming as a hallmark of cancer has facilitated the creation of innovative metabolism-targeted treatment strategies.

Evaluating the cost-effectiveness of prosthetic rehabilitation for partially edentulous teeth in India: A comparative study of Clasp-Retained RPDs, Thermoplastic Resin RPDs, and Cast Partial Dentures.

Background: With rising life expectancy, partial edentulism has increased, particularly in developing nations where economic constraints, limited awareness, and inadequate dental care exacerbate the burden on aging populations. Patients with fewer than 20 teeth often experience a reduction in Oral Health-Related Quality of Life (OHRQoL), emphasizing the need for effective tooth replacement. Removable partial dentures (RPDs) are versatile, cost-effective solutions for partial tooth loss, including metal clasp-retained RPDs (MC-RPDs), thermoplastic resin RPDs (TR-RPDs), and cast partial dentures (CPDs).

FHD deep learning prognosis approach: Early detection of fetal heart disease (FHD) using ultrasonography image-based IROI combined multiresolution DCNN.

Fetal Heart Disease (FHD) is the most prevalent root cause of infant demise which accounts for 21% of all congenital abnormalities, with most instances being catastrophic, thereby rendering the need for early prognosis. Ultrasonography is the forefront imaging modality for assessing fetal growth in four-chamber and blood vessel malformation. Clinically diagnosing the abnormality is time-consuming and requires the skill of a radiologist.

Modulation of peptidoglycan recognition protein expression alters begomovirus vectoring efficiency and fitness of Bemisia tabaci.

Peptidoglycan recognition proteins (PGRPs) are evolutionarily conserved molecules. Their role in the immune response to invading pathogens makes them a natural target for viral defence study in a wide range of organisms. Silverleaf whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) is one of the invasive insect pests and transmits begomoviruses in a circulative and persistent manner to vegetables, legumes, fibres and ornamentals.

BIF-induced ROS-mediated cytotoxicity and genotoxicity in embryonic cell culture of Daphnia magna.

Bifenthrin (BIF) is a widely used synthetic pyrethroid insecticide that poses significant risks to the environment, particularly to aquatic ecosystems. In the present study, the cytotoxic and genotoxic effects of BIF on Daphnia magna cells were evaluated using in vitro methods. To achieve this, we developed a novel embryonic cell culture system from D.

seeds capped calcium oxide nano particles - anti-microbial, antioxidant, anti-ulcer analysis.

Calcium Oxide (CaO) is the best replica of logically plentiful earth metal oxides. CaO nanoparticles include sphere-shaped or faceted elevated surface area and magnetic nanostructured particles. The current study give the information regarding booming synthesis of calcium oxide nanoparticles using calcium chloride as precursor and seed extract as capping agent.

Unravelling the wound healing efficiency of 3D bioprinted alginate-gelatin-diethylaminoethyl cellulose-fibrinogen based skin construct in a rat's full thickness wound model.

The skin, being the largest external organ, is highly vulnerable to injuries. To address the donor skin scarcity, tissue engineering and regenerative medicine have emerged as an alternative strategies to skin grafting over the past few decades. Recent advancements in 3D bioprinting technology however, have positioned it as a promising tool for constructing tissue that closely mimics in-vivo conditions, using a variety of biomaterials to meet the demands of tissue repair.

Protein extraction from detoxified cassava leaves using various deep eutectic solvents: A sustainable strategy to enhance nutritional and functional properties.

Cassava (Manihot esculenta) leaves, containing 20-30 % protein and essential amino acids (EAAs), present a promising source of sustainable plant-based protein alternatives. Deep eutectic solvent (DES) offers an eco-friendly, emerging solution for qualitative protein with great functionality, superior to the alkaline extraction-isoelectric precipitation (AE-IP). In this study, the protein extraction from detoxified cassava leaves using eight DESs composed of various HBAs and HBDs.

Role of mordenite zeolite in improving nutrient and water use efficiency in Alfisols.

Poor nutrient use efficiency (NUE) and water use efficiency (WUE) is a predominantly faced problem in semi-arid regions that limit the crop production. This problem can be addressed with the application of zeolite that is a naturally available mineral with very high cation exchange and water holding capacity, which aids in improving NUE and WUE. Moreover, zeolites are safe for the environment and living organisms, and their use in agriculture results in improving physical and chemical properties of soil.

IoT-based triboelectric nanogenerator for wrist pulse acquisition and analysis.

Wrist pulse plays a critical role in prediction and diagnosis of blood pressure (BP)-related illnesses. Therefore, a low-cost, noninvasive and cuffless BP measurement is highly anticipated. Hence, this study reports a triboelectric nanogenerator to harvest signals for BP measurement.

A preliminary assessment of microplastics in the waters and sediments of the second-largest freshwater lagoon in India.

Pulicat is India's second-largest freshwater lagoon having unique biological ecosystem and economical importance. The lagoon systems are highly polluted by the microplastics (MP) due to anthropogenic activity and microplastics are highly emerging kind of contaminant in the environment. Samples were collected from a part of the lagoon near the mouth region.

The Microbiota-Gut-Brain Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Narrative Review of an Emerging Field.

The intricate relationship between gut microbiota and the brain has emerged as a pivotal area of research, particularly in understanding myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This complex condition is characterized by debilitating fatigue, cognitive dysfunction, and a wide array of systemic manifestations, posing significant challenges for diagnosis and treatment. Recent studies highlight the microbiota-gut-brain axis as a crucial pathway in ME/CFS pathophysiology, suggesting that alterations in gut microbial composition may impact immune responses, neurochemical signaling, and neuronal health.