[The rational diagnostic of cholangiocarcinoma].

Cholangiocarcinoma (CC) is a rare malignant tumour arising from cholangiocytes, and its prognosis is usually unfavourable, mostly as a result of late diagnosis of the tumour. The current incidence of cholangiocarcinoma in the Czech Republic is 1.4/100,000 inhabitants per year; in less than 30 % of patients with CC, one of the known risk factors can be identified, most frequently, primary sclerosing cholangitis.

Clinical stages in patients with primary and subsequent cancers based on the czech cancer registry 1976-2005.

Of 1,486,984 new cancers registered in the Czech Cancer Registry in 1976-2005, 290,312 (19.5%) were multiple malignant neoplasms (MMNs), of which there were 65,292 primary and 89,796 subsequent cases in men and 59,970 primary and 75,254 subsequent cases in women. The duplicities were higher in women, and the triplicities and others (3-6 MMNs) were higher in men.

Immunoglobulin G4-related cholangitis: a variant of IgG4-related systemic disease.

IgG4-related sclerosing cholangitis as part of IgG4 systemic-related diseases is commonly associated with autoimmune pancreatitis. Major clinical manifestations of IgG4-related sclerosing diseases are apparent in the organs in which tissue fibrosis with obstructive phlebitis is pathologically induced. IgG4-related sclerosing cholangitis is included within the heterogeneous group of 'sclerosing cholangitis'.

[The expected worldwide burden of oesophagus, stomach and colorectal cancers].

According database of Globocan 2008 of total 482 thousand worldwide new esophagel cancers are reported 16.9% cases in more developed and 83.1% in less developed regions, 6.

[Chronic pancreatitis in 2011].

The incidence of chronic pancreatitis grows slowly but steadily. At present, alcohol is the most frequent risk factor, although the new forms of so called non-alcoholic chronic pancreatitis, such as genetically induced pancreatitis and its autoimmune variety, are carefully watched. Alcohol consumption continues to be most closely associated with the disease, though it is no more than a risk factor and other aspects, e.

[International health statistics databases and available data].

The relevant data and information is necessary for the correct decision making. It applies also in case of health system management. Nowadays, many international databases of health data are available.

[Autoimmune pancreatitis and IgG-positive sclerosing cholangitis].

Sclerosing cholangitis is a heterogenous disease. Sclerosing cholangitis with an unknown cause is abbreviated PSC. PSC affects extra- as well as intra-hepatic bile ducts and since this is a permanently progressing fibrous condition, it leads to liver cirrhosis.

[Pancreatic cancer--association with diabetes mellitus and smoking].

Introduction: Pancreatic cancer is a disease with rather poor prognosis. This can be explained, among other reasons, by unusually aggressive course of the tumour growth and, in the majority of cases, late, and thus further treatment limiting, diagnosis. In addition, no effective screening programme for pancreatic cancer is available and thus identification of risk factors associated with the development of pancreatic cancer represents a possible approach to diagnosing early stages of the disease.

Trends of primary and subsequent cancers of the gastrointestinal tract in the Czech population, 1976-2005.

A total of 355,624 new gastrointestinal (GI) cancers were registered in 1976-2005 in the Czech Cancer Registry. Of these, there were 14,744 (4.1%) primary and 26,790 (7.

[Cancer multiplicities in the Czech population].

During 1976-2005 the Czech Cancer Registry registered 1.486,984 neoplasms of categories ICD-10: C00-D48, of which were notified 290,312 (19.5%) multiple cases.

[Trends in cancer incidence in the Czech Republic].

In general, the cancer incidence becomes stabilized in the Czech Republic during last years. However, the incidence of colorectal and renal cancers remains increasing and dominates also in European comparisons. A program of cancer prevention and early detection needs to be established at least for six so called preventable cancers as breast, lung, colorectal, cervical and prostatic carcinomas and malignant melanoma, which represent together 40 % of all oncological cases.

[Cryopreservation of sperm before neoplasm therapy--7 years' experience].

Objective: To compare sperm count of cancer patients with health men, to analyze possible relation of sperm pathology and diagnosis of malignant disease and present experience of our cryopreservation programme for cancer patients.

Design: Retrospective clinical study.

Setting: Department of Obstetrics and Gynecology, Masaryk University, Brno, Czech Republic.

[Support for cancer research and therapy with regard to its incidence].

With the current annual incidence of about 63,000 new cancers in the Czech Republic and with 320,000 treated diseases it is necessary to make use of all experience to warn the population against cancer. The treatment of more than 8 million oncological patients in the U.S.

[Smoking in the United States and Europe].

Article reports on new findings in smoking prevalence, incidence of cancer and preventive actions against smoking in the United States and some countries in Europe. Situation in the Czech Republic is described and data from the National Cancer Registry are included.

Childhood leukaemia in Europe after Chernobyl: 5 year follow-up.

The European Childhood Leukaemia - Lymphoma Incidence Study (ECLIS) is designed to address concerns about a possible increase in the risk of cancer in Europe following the nuclear accident in Chernobyle in 1986. This paper reports results of surveillance of childhood leukaemia in cancer registry populations from 1980 up to the end of 1991. There was a slight increase in the incidence of childhood leukaemia in Europe during this period, but the overall geographical pattern of change bears no relation to estimated exposure to radiation resulting from the accident.