Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial.

Epistaxis greatly affects patients with hereditary hemorrhagic telangiectasia (HHT). Although few systemic treatment exist, nintedanib, is a good candidate thanks to its anti-angiogenic activity. Our main objective was to evaluate the efficacy of oral nintedanib on epistaxis duration in HHT patients with moderate to severe epistaxis.

SPIDOL study protocol for the assessment of intrathecal ziconotide antalgic efficacy for severe refractory neuropathic pain due to spinal cord lesions.

Rationale: Central neuropathic pain resulting from spinal cord injury is notoriously debilitating and difficult to treat with few currently available treatments. A novel molecule with intrathecal administration: Ziconotide has been approved for treatment of refractory neuropathic pain in general. It acts as a presynaptic calcium channel blocker.

Invertebrate sounds from photic to mesophotic coral reefs reveal vertical stratification and diel diversity.

Although mesophotic coral ecosystems account for approximately 80% of coral reefs, they remain largely unexplored due to their challenging accessibility. The acoustic richness within reefs has led scientists to consider passive acoustic monitoring as a reliable method for studying both altiphotic and mesophotic coral reefs. We investigated the relationship between benthic invertebrate sounds (1.

Biogeography of acoustic biodiversity of NW Mediterranean coralligenous reefs.

Monitoring the biodiversity of key habitats and understanding the drivers across spatial scales is essential for preserving ecosystem functions and associated services. Coralligenous reefs are threatened marine biodiversity hotspots that are challenging to monitor. As fish sounds reflect biodiversity in other habitats, we unveiled the biogeography of coralligenous reef sounds across the north-western Mediterranean using data from 27 sites covering 2000 km and 3 regions over a 3-year period.

How human activity impacted manufacturing non-compliances: A multivariate analysis in a centralized cytotoxic preparation unit.

Introduction: The aim of the study was to identify risk factors related to human errors in the preparation of anticancer drugs in order to improve the pharmaceutical process by setting corrective actions.

Method: Risk factors which could increase the probability of error were identified: daily workload, workload on the previous day and subcontractors' workload, time slot of the preparation, understaffing, incidents which could affect workflow, individual experience of technicians and cleanrooms layout. Drug reconstitution or complex fabrications were also considered as risk factors.

Acoustic and photographic monitoring of coastal maritime traffic: Influence on the soundscape.

Due to the absence of Automatic Identification System data (used by 3.7% of the Calvi bay fleet), the acoustic monitoring of coastal environments presents difficulties. A specific visual monitoring protocol has been set up on a photographic observatory using the wide-angle camera GoPro.

Do systemic treatments delivered after Nivolumab result in better outcomes? A bicentric case-control study.

Background: Immune checkpoint inhibitors (ICI) are now widely used at different stages of non-small cell lung cancers (NSCLC). Some clinical studies suggest that chemotherapy and immunotherapy have synergic activities, raising the question of the best therapeutic sequence. We studied the effect of chemotherapy in advanced NSCLC when administered after immunotherapy by nivolumab.

Fish biophony in a Mediterranean submarine canyon.

Although several bioacoustics investigations have shed light on the acoustic communication of Mediterranean fish species, the occurrence of fish sounds has never been reported below -40 m depth. This study assessed the occurrence of fish sounds at greater depths by monitoring the soundscape of a Mediterranean submarine canyon (Calvi, France) thanks to a combination of Static Acoustic Monitoring (three stations, from -125 to -150 m depth, 3 km from coastline) and of hydrophone-integrated gliders (Mobile Acoustic Monitoring; from -60 to -900 m depth, 3-6 km from coastline). Biological sounds were detected in 38% of the audio files; ten sound types (for a total of more than 9.

Sea chordophones make the mysterious /Kwa/ sound: identification of the emitter of the dominant fish sound in Mediterranean seagrass meadows.

The /Kwa/ vocalization dominates the soundscape of meadows but the identity of the species emitting this peculiar fish sound remains a mystery. Information from sounds recorded in the wild indicates that the emitting candidates should be abundant, nocturnal and benthic. spp.

Underwater operational noise level emitted by a tidal current turbine and its potential impact on marine fauna.

Marine renewable energy development raised concerns over the impact of underwater noise. Here we assess the acoustic impacts of an operating tidal current turbine (Paimpol-Bréhat site, France) on marine fauna. Its source level (SL) has been measured in situ using 19 drifting transects at distances between 100 m to 2400 m from the turbine.

Automatic fish sounds classification.

The work presented in this paper focuses on the use of acoustic systems for passive acoustic monitoring of ocean vitality for fish populations. Specifically, it focuses on the use of acoustic systems for passive acoustic monitoring of ocean vitality for fish populations. To this end, various indicators can be used to monitor marine areas such as both the geographical and temporal evolution of fish populations.

Effects of shipping on marine acoustic habitats in Canadian Arctic estimated via probabilistic modeling and mapping.

Canadian Arctic and Subarctic regions experience a rapid decrease of sea ice accompanied with increasing shipping traffic. The resulting time-space changes in shipping noise are studied for four key regions of this pristine environment, for 2013 traffic conditions and a hypothetical tenfold traffic increase. A probabilistic modeling and mapping framework, called Ramdam, which integrates the intrinsic variability and uncertainties of shipping noise and its effects on marine habitats, is developed and applied.

Analysis and modeling of 255 source levels of merchant ships from an acoustic observatory along St. Lawrence Seaway.

An ensemble of 255 spectral source levels (SSLs) of merchant ships were measured with an opportunistic seaway acoustic observatory adhering to the American National Standards Institute/Acoustical Society of America S12.64-2009 standard as much as possible, and deployed in the 350-m deep lower St. Lawrence Seaway in eastern Canada.

Validation of trophic and anthropic underwater noise as settlement trigger in blue mussels.

Like the majority of benthic invertebrates, the blue mussel Mytilus edulis has a bentho-pelagic cycle with its larval settlement being a complex phenomenon involving numerous factors. Among these factors, underwater noise and pelagic trophic conditions have been weakly studied in previous researches. Under laboratory conditions, we tested the hypothesis that picoplankton assimilation by the pediveliger blue mussel larvae acts as a food cue that interacts with anthropic underwater sound to stimulate settlement.

Whistle source levels of free-ranging beluga whales in Saguenay-St. Lawrence marine park.

Wild beluga whistle source levels (SLs) are estimated from 52 three-dimensional (3D) localized calls using a 4-hydrophone array. The probability distribution functions of the root-mean-square (rms) SL in the time domain, and the peak, the strongest 3-dB, and 10-dB SLs from the spectrogram, were non-Gaussian. The average rms SL was 143.

Wind dependence of ambient noise in a biologically rich coastal area.

The wind dependence of acoustic spectrum between 100 Hz and 16 kHz is investigated for coastal biologically rich areas. The analysis of 5 months of continuous measurements run in a 10 m deep shallow water environment off Brittany (France) showed that wind dependence of spectral levels is subject to masking by biological sounds. When dealing with raw data, the wind dependence of spectral levels was not significant for frequencies where biological sounds were present (2 to 10 kHz).

Illuminating the binding interactions of galactonoamidines during the inhibition of β-galactosidase (E. coli).

Several galactonoamidines were previously identified as very potent competitive inhibitors that exhibit stabilizing hydrophobic interactions of the aglycon in the active site of β-galactosidase (Aspergillus oryzae). To elucidate the contributions of the glycon to the overall inhibition ability of the compounds, three glyconoamidine derivatives with alteration in the glycon at C-2 and C-4 were synthesized and evaluated herein. All amidines are competitive inhibitors of β-galactosidase (Escherichia coli) and show significantly reduced inhibition ability when compared to the parent.

A Seaway Acoustic Observatory in Action: The St. Lawrence Seaway.

A setup for measuring spectral source levels (SSLs) of ships transiting along a seaway, the traffic density and shipping noise, is presented. The results feed shipping-noise modeling that reproduces the actual in situ observations to map shipping-noise variability over space and time for investigating its effects on aquatic organisms. The ship's SSL databank allows sorting the different contributors to total shipping noise for assisting in exploring mitigation approaches (e.

Arctic underwater noise transients from sea ice deformation: Characteristics, annual time series, and forcing in Beaufort Sea.

A 13-month time series of Arctic Ocean noise from the marginal ice zone of the Eastern Beaufort Sea is analyzed to detect under-ice acoustic transients isolated from ambient noise with a dedicated algorithm. Noise transients due to ice cracking, fracturing, shearing, and ridging are sorted out into three categories: broadband impulses, frequency modulated (FM) tones, and high-frequency broadband noise. Their temporal and acoustic characteristics over the 8-month ice covered period, from November 2005 to mid-June 2006, are presented and their generation mechanisms are discussed.

Mapping probability of shipping sound exposure level.

Mapping vessel noise is emerging as one method of identifying areas where sound exposure due to shipping noise could have negative impacts on aquatic ecosystems. The probability distribution function (pdf) of sound exposure levels (SEL) is an important metric for identifying areas of concern. In this paper a probabilistic shipping SEL modeling method is described to obtain the pdf of SEL using the sonar equation and statistical relations linking the pdfs of ship traffic density, source levels, and transmission losses to their products and sums.

Cyclodextrin nanoassemblies: a promising tool for drug delivery.

Among the biodegradable and nontoxic compounds that can form nanoparticles for drug delivery, amphiphilic cyclodextrins are very promising. Apart from ionic cyclodextrins, which have been extensively studied and reviewed because of their application in gene delivery, our purpose is to provide a clear description of the supramolecular assemblies of nonionic amphiphilic cyclodextrins, which can form nanoassemblies for controlled drug release. Moreover, we focus on the relationship between their structure and physicochemical characteristics, which is crucial for self assembly and drug delivery.

Automated segmentation of linear time-frequency representations of marine-mammal sounds.

Many marine mammals produce highly nonlinear frequency modulations. Determining the time-frequency support of these sounds offers various applications, which include recognition, localization, and density estimation. This study introduces a low parameterized automated spectrogram segmentation method that is based on a theoretical probabilistic framework.

Under-ice ambient noise in Eastern Beaufort Sea, Canadian Arctic, and its relation to environmental forcing.

This paper analyzes an 8-month time series (November 2005 to June 2006) of underwater noise recorded at the mouth of the Amundsen Gulf in the marginal ice zone of the western Canadian Arctic when the area was >90% ice covered. The time-series of the ambient noise component was computed using an algorithm that filtered out transient acoustic events from 7-min hourly recordings of total ocean noise over a [0-4.1] kHz frequency band.