Publications by authors named "Gervais Ntakirutimana"
Article Synopsis
- * In a cohort of 51 CRC patients from Rwanda, TP53 variants were found in 45.1% of cases, primarily of the missense type, with notable mutations including c.455dup, c.524G>A, and c.733G>A, and a predominance of specific mutation sequences.
- * The study also revealed that most TP53 mutations were associated with the CMS2 subtype, suggesting that these variants may play a significant role in the development of this
Background: Gastric cancer is the sixth most frequently diagnosed cancer and third in causing cancer-related death globally. The most frequently mutated gene in human cancers is TP53, which plays a pivotal role in cancer initiation and progression. In Africa, particularly in Rwanda, data on TP53 mutations are lacking.
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- Cancer research in Rwanda accounts for less than 1% of Africa's total output, with limited studies on colorectal cancer (CRC), which predominantly affects younger females and often presents at an advanced stage.
- Researchers conducted a study on CRC tissue mutations, focusing on specific genes, through Sanger sequencing of samples from 54 patients, revealing a high prevalence of low-grade tumors primarily in the rectum.
- The study identified 27 genetic variants, including three novel deleterious mutations, and provided important genetic variations and clinical information regarding CRC in the Rwandan population.
Purpose: In most low- and lower middle-income countries (LMICs), minimally invasive tissue sampling (MITS) is a relatively new procedure for identifying the cause of death (CoD). This study aimed to explore perceptions and acceptance of bereaved families and health-care professionals regarding MITS in the context of MITS initiation in Rwanda as an alternative to clinical autopsy.
Methods: This was a qualitative phenomenological study with thematic analysis.
Background: Low- and middle-income countries (LMICs) face disproportionately high mortality rates, yet the causes of death in LMICs are not robustly understood, limiting the effectiveness of interventions to reduce mortality. Minimally invasive tissue sampling (MITS) is a standardized postmortem examination method that holds promise for use in LMICs, where other approaches for determining cause of death are too costly or unacceptable. This study documents the costs associated with implementing the MITS procedure in LMICs from the healthcare provider perspective and aims to inform resource allocation decisions by public health decisionmakers.
View Article and Find Full Text PDFBackground: Minimally invasive tissue sampling (MITS) is a useful tool to determine cause of death in low- and middle-income countries (LMICs). In 2019 the MITS Surveillance Alliance supported the implementation of small-scale postmortem studies using MITS in several LMICs.
Methods: In this article we describe the preparations, challenges, and lessons learned as part of implementing MITS across 4 study sites in 3 countries: Nepal, Rwanda, and Tanzania.