Durvalumab after Sequential High Dose Chemoradiotherapy versus Standard of Care (SoC) for Stage III NSCLC: A Bi-Centric Trospective Comparison Focusing on Pulmonary Toxicity.

Introduction: The standard of care (SoC) for unresectable stage III non-small-cell lung cancer (NSCLC) is durvalumab maintenance therapy after concurrent chemoradiation in patients with PD-L1 > 1%. However, the concurrent approach is only amenable for about one-third of patients due to co-morbidities. Although sequential regimens are usually not regarded as curative, these schedules applied in a dose-escalated manner may be similarly radical as SoC.

Acute Exposure to Environmental Tobacco Smoke: A Controlled Study in Adults with Asthma.

Background: Short-term, indoor exposure to environmental tobacco smoke (ETS) is still highly prevalent; however, little is known about the acute lung response in adult asthma.

Objectives: We investigated whether acute, experimental ETS exposure influences symptoms, lung function, and inflammatory parameters.

Methods: Human subjects with asthma (n = 23) were exposed for 180 min to either room air or ETS at 250, 450, or 850 µg/m3.

Role of Breathing Conditions During Exercise Testing on Training Prescription in Chronic Obstructive Pulmonary Disease.

This study investigated whether different breathing conditions during exercise testing will influence measures of exercise capacity commonly used for training prescription in chronic obstructive pulmonary disease. Twenty-seven patients with chronic obstructive pulmonary disease (forced expiratory volume in 1 sec = 45.6 [9.

Development and validation of the Salzburg COPD-screening questionnaire (SCSQ): a questionnaire development and validation study.

Unlabelled: Chronic obstructive pulmonary disease prevalence rates are still high. However, the majority of subjects are not diagnosed. Strategies have to be implemented to overcome the problem of under-diagnosis.

Supplemental Oxygen During High-Intensity Exercise Training in Nonhypoxemic Chronic Obstructive Pulmonary Disease.

Background: Physical exercise training is an evidence-based treatment in chronic obstructive pulmonary disease, and patients' peak work rate is associated with reduced chronic obstructive pulmonary disease mortality. We assessed whether supplemental oxygen during exercise training in nonhypoxemic patients with chronic obstructive pulmonary disease might lead to superior training outcomes, including improved peak work rate.

Methods: This was a randomized, double-blind, controlled, crossover trial.

Detection of chronic obstructive pulmonary disease in primary care in Salzburg, Austria: findings from the real world.

Background: Chronic obstructive pulmonary disease (COPD) is a major public health burden and profoundly affects individuals suffering from the disease. However, the majority of subjects with COPD are still undiagnosed.

Objectives: To evaluate COPD prevalence and detection strategies for COPD in the primary-care setting.

Not all farming environments protect against the development of asthma and wheeze in children.

Background: In recent years, studies have shown a protective effect of being raised in a farm environment on the development of hay fever and atopic sensitization. Inconsistent data on the relation of farming to asthma and wheeze have raised some doubt about a true protective effect.

Objective: We sought to study the differential effects of farm-associated exposures on specific asthma-related health outcomes.

[Parental satisfaction with an outpatient asthma-management program for children and adolescents--a pilot study].

The objective of our asthma management program is to optimize the disease management and the quality of life of children and adolescents with asthma. An improvement in coping with asthma should be achieved by teaching theoretical aspects and practical skills. The training is performed in small groups of children and adolescents of similar age, going for 10 sessions each lasting 90 minutes.