Work-related Fatigue: Relationship between Perceived and Performance Fatigability in Career Firefighters.

Objective: The purpose of this study was to 1) examine the relationship between perceived work-related fatigue and performance fatigability, and 2) assess the impact of percent body fat (%BF) on perceived fatigue constructs in career firefighters.

Methods: Thirty-nine career firefighters completed body composition testing, the Occupational Fatigue Exhaustion Recovery (OFER15) scale assessing three subscales of work-related fatigue (acute fatigue, chronic fatigue, and inter-shift recovery), and maximal leg extensor isometric strength testing prior to and following an isotonic fatiguing protocol.

Results: Performance fatigability was not associated with any of the OFER15 perceived work-related fatigue variables ( P ≥ 0.

The impact of inter-limb leg lean tissue mass asymmetry on stair climb performance in career firefighters.

The purpose of this study was to examine the influence of inter-limb leg lean tissue mass (LTM) asymmetry on stair climb (SC) performance in firefighters. Forty-one career firefighters (age = 32.3 ± 8.

The feasibility of workload monitoring among law enforcement officers: A multi-methodological approach.

This study examined the feasibility of workload monitoring to assess internal workload in law enforcement officers (LEO) using a multi-methodological approach. Fifty front-line LEO completed workload surveys on workdays for eight weeks. Retention and adherence were assessed across the survey period.

Impact of Age on the Affective Responses Following Worksite Resistance Exercise in Career Firefighters.

Introduction: The purpose of this study was to examine the impact of age on the affective responses (attitude, feelings, self-efficacy, intention, enjoyment, and fondness) after a worksite circuit-style resistance exercise routine in career firefighters.

Methods: Nineteen young (25.5 ± 3.

Phase II Study of Docetaxel and Trametinib in Patients with KRAS Mutation Positive Recurrent Non-Small Cell Lung Cancer (NSCLC; SWOG S1507, NCT-02642042).

Purpose: Efficacy of MEK inhibitors in KRAS+ NSCLC may differ based on specific KRAS mutations and comutations. Our hypothesis was that docetaxel and trametinib would improve activity in KRAS+ NSCLC and specifically in KRAS G12C NSCLC.

Patients And Methods: S1507 is a single-arm phase II study assessing the response rate (RR) with docetaxel plus trametinib in recurrent KRAS+ NSCLC and secondarily in the G12C subset.

Test-Retest Reliability and Minimum Difference Values of a Novel and Portable Upright Row Strength Assessment in Probation Officers.

Upper body (UB) strength is important for occupational tasks and injury prevention in law enforcement officers (LEOs). Portable, reliable, and cost-effective assessments are needed to examine UB strength among LEOs in field settings. The purpose of this study was to examine the test-retest reliability and minimum difference (MD) values of a novel and portable isometric upright row assessment in probation officers.

The Time Course of Health, Fitness, and Occupational Performance Changes in Recruits across a Fire Academy.

Purpose: The purpose of this study was to examine the time course of health, fitness, and occupational performance changes in firefighter recruits across a fire academy.

Methods: Nineteen recruits (24.9 ± 4.

Case Report of Multisystem Inflammatory Syndrome in Adults (MIS-A): A 31-Year-Old Man with Fever, Rash, and Cardiac Symptoms 6 Weeks Following SARS-CoV-2 Infection, Successfully Resuscitated Following Cardiac Arrest.

BACKGROUND Multisystem inflammatory syndrome in adults (MIS-A) is an uncommon condition after a confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, manifesting as multiorgan failure despite apparent resolution of initial symptoms. While this syndrome shares similar characteristics with a syndrome found in children, fewer cases are reported in adults. This report details a 31-year-old man fulfilling the diagnostic criteria of MIS-A, who was successfully resuscitated following cardiac arrest.

"Near Cure" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct.

Our previous studies demonstrated increased serum levels of macrophage migration inhibitory factor (MIF-1) and its homologue, MIF-2, in males during MS progression; and that genetically high-MIF-expressing male subjects with relapsing multiple sclerosis (MS) had a significantly greater risk of conversion to progressive MS than lower-MIF-expressing males and females. However, female MS subjects with severe disease expressed higher levels of CD74, the common MIF-1/MIF-2 receptor, on blood cells. In the murine model of MS, experimental autoimmune encephalomyelitis (EAE), both male and female mice lacking MIF-1 and/or MIF-2 were clinically improved during development of moderately severe disease, thus implicating both homologs as co-pathogenic contributors.

Examining the Usability of Workload Monitoring in Firefighter Recruits.

Objective: Although workload monitoring is commonly used in athletic settings to mitigate injury risk, we are unaware of previous studies examining its feasibility among firefighters.

Methods: Nineteen firefighter recruits completed a short online workload survey at the end of each training day (Monday-Friday) for 26 weeks during the academy. A modified System Usability Scale was provided at midtesting (3 months into the academy) and posttesting (end of the academy).

Not So Sweet Sweet's Syndrome: A Case of Acute Febrile Neutrophilic Dermatosis in the Treatment of Ovarian Carcinoma.

Background: Acute febrile neutrophilic dermatosis, or Sweet's Syndrome (SS), was first characterized by Dr. Robert Sweet in 1964 with eight cases of fever, neutrophilic polymorphonuclear leukocytosis, dermatological lesions, and histological evidence of dense dermal infiltration by mature neutrophils. SS presents in three settings: idiopathic, malignancy-associated, and drug-induced.

Segmental bioelectrical impedance spectroscopy: A novel field assessment of muscle size and quality in normal weight and obese older men.

The purpose of this study was to determine if segmental bioelectrical impedance spectroscopy characteristic frequency (f) and phase angle (P) were reflective of differences in quadriceps muscle size and quality, respectively, in normal weight and obese older men, and to assess the impact of hydration status on these measurements. Forty-one healthy older men volunteered for this study and were recruited by age (65-74 years) and two body mass index groups: normal weight and obese. Participants visited the laboratory on one occasion where they underwent a hydration status assessment via urine specific gravity, a percent body fat assessment via dual-energy X-ray absorptiometry, a segmental bioelectrical impedance spectroscopy thigh assessment to determine f and P, and resting ultrasonography to assess superficial quadriceps cross-sectional area and echo intensity as a proxy for muscle quality.

The impact of repeated bouts of shiftwork on rapid strength and reaction time in career firefighters.

The purpose of this study was to examine the influence of repeated bouts of shiftwork on lower extremity maximal and rapid strength and reaction time in career firefighters. Thirty-five firefighters (3 females; 34.3 ± 9.

The Influence of Sonographer Experience on Skeletal Muscle Image Acquisition and Analysis.

The amount of experience with ultrasonography may influence measurement outcomes while images are acquired or analyzed. The purpose of this study was to identify the interrater reliability of ultrasound image acquisition and image analysis between experienced and novice sonographers and image analysts, respectively. Following a brief hands-on training session (2 h), the experienced and novice sonographers and analysts independently performed image acquisition and analyses on the biceps brachii, vastus lateralis, and medial gastrocnemius in a sample of healthy participants ( = 17).

Brief report: Enhanced DRα1-mMOG-35-55 treatment of severe EAE in MIF-1-deficient male mice.

Macrophage migration inhibitory factor (MIF-1) and its homologue d-dopachrome tautomerase (MIF-2) share the common CD74 receptor and function innately to enhance severity of multiple sclerosis (MS) as well as the experimental autoimmune encephalomyelitis (EAE) model for MS. We previously demonstrated that genetically high-MIF-expressing male subjects with relapsing MS had a significantly greater risk of conversion to progressive MS (PMS) than lower-MIF-expressing males. To expand on this observation, we utilized MIF-1, MIF-2, and MIF-1/2-DUAL-deficient male mice to discern if there would be a greater contribution of these inflammatory factors in EAE mice with severe vs.

Neuromuscular determinants of simulated occupational performance in career firefighters.

Purpose: Although firefighters are required to perform various high-intensity critically essential tasks, the influence of neuromuscular function on firefighter occupational performance is unclear. The primary aim of the current study was to identify the key neuromuscular determinants of stair climb (SC) performance in firefighters.

Methods: Leg extension isometric peak torque (PT), peak power (PP), torque steadiness at 10% (Steadiness) and 50% (Steadiness) of PT, fatigability following 30 repeated isotonic concentric contractions at 40% of PT, percent body fat (%BF), and a weighted and timed SC task were examined in 41 (age: 32.

The influence of age on the recovery from worksite resistance exercise in career firefighters.

Unlabelled: Resistance exercise is an important strategy to reduce injuries and improve performance in the fire service. However, given the large age range of firefighters, it is important to determine if age influences their recovery following an acute bout of resistance exercise.

Purpose: To examine the changes in indirect markers of muscle damage in young and older firefighters following a feasible worksite resistance exercise routine.

Measuring muscle quality: associations between echo intensity and normalized strength and power.

. Muscle quality has received considerable attention within the literature due to its influence on health and performance. However, it has been assessed by various measures (e.

Sex differences in EAE reveal common and distinct cellular and molecular components.

Experimental autoimmune encephalomyelitis (EAE) is commonly used as an animal model for evaluating clinical, histological and immunological processes potentially relevant to the human disease multiple sclerosis (MS), for which the mode of disease induction remains largely unknown. An important caveat for interpreting EAE processes in mice is the inflammatory effect of immunization with myelin peptides emulsified in Complete Freund's Adjuvant (CFA), often followed by additional injections of pertussis toxin (Ptx) in some strains to induce EAE. The current study evaluated clinical, histological, cellular (spleen), and chemokine-driven processes in spinal cords of male vs.

Pathogenesis of Human Immunodeficiency Virus- Co-Infection.

Given that infection with () is the leading cause of death amongst individuals living with HIV, understanding the complex mechanisms by which exacerbates HIV infection may lead to improved treatment options or adjuvant therapies. While it is well-understood how HIV compromises the immune system and leaves the host vulnerable to opportunistic infections such as , less is known about the interplay of disease once active is established. This review explores how glutathione (GSH) depletion, T cell exhaustion, granuloma formation, and TNF-α upregulation, as a result of infection, leads to an increase in HIV disease severity.

The Influence of Age and Obesity-Altered Muscle Tissue Composition on Muscular Dimensional Changes: Impact on Strength and Function.

The purpose of this study was to determine if muscular dimensional changes with increases in torque production are influenced by age- and obesity-related increases in intramuscular fat, and its relationship to percent body fat (%BF), echo intensity (EI), strength, and maximum walking speed. Sixty-six healthy men were categorized into 3 groups based on age and body mass index status (young normal weight [YNW], older normal weight [ONW], and older obese [OB]). Participants underwent %BF assessments, resting ultrasonography to determine muscle size (cross-sectional area [CSA]) and EI of the superficial quadriceps, and a 10-m maximum walking speed assessment.

Over-the-counter bite splints: A randomized controlled trial of compliance and efficacy.

Background: Occlusal splints are often used to curb the impacts of sleep bruxism (SB) on the dentition, and over-the-counter (OCT) options are becoming increasingly popular. OTC splints are usually fabricated at home by patients, but not routinely evaluated by dental professionals. It is unclear how OCT splints compare with more traditional splints that receive dental oversight.

The Acute Effects of a Multi-Ingredient Herbal Supplement on Performance Fatigability: A Double-Blind, Randomized, and Placebo-Controlled Trial.

The purpose of the present study was to examine the acute effects of an herbal supplement containing a 70:30 blend of Rhaponticum carthamoides extract and Rhodiola rosea extract, respectively, on performance fatigability and the affective responses prior to and following exercise. Thirty men (age = 22.3 ± 4.

Endoscopic Flexor Hallucis Longus Transfer for Achilles Noninsertional Tendinopathy: Description of Surgical Technique and Functional Outcomes.

. The transfer of the flexor hallucis longus (FHL) tendon is an established treatment for replacing a dysfunctional Achilles tendon. .