Clinical Research Network: JHCRN Infrastructure and Lessons Learned.

Clinical research studies are becoming increasingly complex resulting in compounded work burden and longer study cycle times, each fueling runaway costs. The impact of protocol complexity often results in inadequate recruitment and insufficient sample sizes, which challenges validity and generalizability. Understanding the need to provide an alternative model to engage researchers and sponsors and bringing clinical research opportunities to the broader community, clinical research networks (CRN) have been proposed and initiated in the United States and other parts of the world.

A Qualitative Study of Midlevel Nurse Managers' Perspectives of Scholarly Inquiry.

Objective: This study explored the key characteristics and needs of midlevel nurse managers (MLNMs) who support and engage clinical nurses (CNs) in scholarly inquiry.

Background: Healthcare organizations expect CNs to participate in scholarly inquiry, incorporating evidence-based interventions to improve outcomes and safety. How the MLNM supports and engages CNs in scholarly inquiry remains unclear.

An academic and regional nurse research collaborative: Implications for nursing research.

Introduction: A diverse group of nurses and research Network Coordinators formed a collaboration to advance nursing research within Johns Hopkins Clinical Research Network, a partnership of academic and community hospitals in the mid-Atlantic region. The purpose of the Nurse Research Collaborative (NRC) is to provide mentoring, mutual growth, and assist the health care organizations to fulfill nursing research requirements.

Background: We created a multiinstitutional nursing research organization with diversity of member participants and health care facilities.

Assessing knowledge, attitudes and beliefs of nurses about LGBTQ older adults using a documentary video.

Background: Statistics reveal that lesbian, gay, bisexual, transgender, and queer (LGBTQ) older adults experience health disparities and barriers to accessing healthcare because of discrimination and fear of disclosing sexual orientation. Nurses receive limited education on LGBTQ health issues and even less information specifically about LGBTQ older adults. This study exposed novice nurses to the documentary, Gen Silent, which details LGBTQ older adult experiences.

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.

Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia.

Ocular motor and sensory function in Parkinson's disease.

Purpose: To evaluate the effect of dopaminergic medication and deep brain stimulation on ocular function in Parkinson's disease (PD) and to measure vision-related quality of life in subjects with PD.

Design: Prospective, comparative case series.

Participants And Controls: Twenty-seven PD and 16 control subjects were recruited.

Atomoxetine for the treatment of executive dysfunction in Parkinson's disease: a pilot open-label study.

Executive dysfunction (ED) is a prominent and often disabling feature of cognitive impairment in Parkinson's disease (PD). Few studies have examined treatments. Given the role of noradrenergic pathology in ED, atomoxetine, a norepinephrine reuptake inhibitor indicated for attention deficit hyperactivity disorder (ADHD), may be a potential treatment for PD-related ED.

Bialgebra cohomology, deformations, and quantum groups.

We introduce cohomology and deformation theories for a bialgebra A (over a commutative unital ring k) such that the second cohomology group is the space of infinitesimal deformations. Our theory gives a natural identification between the underlying k-modules of the original and the deformed bialgebra. Certain explicit deformation formulas are given for the construction of quantum groups--i.