Publications by authors named "Gerry A Shipman"

Article Synopsis
  • Methylation of histone 3 lysine 36 (H3K36me) is crucial for gene expression regulation, but understanding the specific enzymes involved remains unclear.* -
  • In mouse stem cells, research reveals that H3K36me2 is mainly added by NSD1 and NSD2 in intergenic regions, while H3K36me1/3 are found in exons, correlating with gene activity; SETD2 is key for H3K36me3 deposition.* -
  • The study identifies a hierarchy among methyltransferases (K36MTs) for adding H3K36me1/2, with NSD1 being the most dominant, while NSD3
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Background: Methylation of histone 3 lysine 36 (H3K36me) has emerged as an essential epigenetic component for the faithful regulation of gene expression. Despite its importance in development, disease, and cancer, how the molecular agents collectively shape the H3K36me landscape is unclear.

Results: We use a mouse mesenchymal stem cell model to perturb the H3K36me deposition machinery and infer the activities of the five most prominent players: SETD2, NSD1, NSD2, NSD3, and ASH1L.

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