Influence of the ceramic translucency on the relative degree of conversion of a direct composite and dual-curing resin cement through lithium disilicate onlays and endocrowns.

Introduction: The goal of this study was to investigate the influence of the ceramic translucency, restoration type and polymerization time on the relative degree of conversion of a dual-curing resin cement and a conventional microhybrid resin composite using a high-power light-curing device.

Methods And Materials: Two 4.0 mm thick onlay (O) and two 7.

Effects of nitrendipine and enalapril on left ventricular mass in patients with non-insulin-dependent diabetes mellitus and hypertension.

Objective: To compare the effects of a calcium antagonist (nitrendipine) and an angiotensin converting enzyme inhibitor (enalapril) with those of placebo on left ventricular mass in patients with non-insulin-dependent diabetes mellitus and hypertension.

Design: A double-blind randomized, placebo-controlled trial.

Setting: General practitioners referred patients to the trial physician.

A source impedance compensated artificial voice for mask speech intelligibility testing: Thevenin model.

This paper describes the development of a Thevenin model of the human voice for mask speech intelligibility testing. The following steps were used to develop the Thevenin model: (1) the long-term average speech spectrum of ten male speakers was measured; (2) the corresponding average vocal tract shape was estimated using linear prediction; (3) a Thevenin model of the voice was determined based on the vocal tract shape. Electroacoustic analogs are used to predict the mask speech spectra produced by the Thevenin model and a mouth simulator consisting of a loudspeaker equalized for free-air speech.

Model studies in adjuvant chemotherapy.

We have focused on three aspects of adjuvant chemotherapy applied to mice with one of the metastasizing tumors: Lewis lung carcinoma (LL) or mammary carcinoma 2661 (M2661). The first aspect concerned the timing of adjuvant chemotherapy. To investigate this, tumor-bearing mice were treated postoperatively with cyclophosphamide using a standard regimen.

Kinetics of l-5-hydroxytryptophan in healthy subjects.

The kinetics of l-5-hydroxytryptophan (5-HTP) were studied in five volunteers after intravenous and oral administration of 5-HTP following pretreatment with carbidopa. In addition, the effect of pretreatment with carbidopa on metabolism and disposition of 5-HTP was studied in eight subjects. The kinetics of 5-HTP following a 20-minute linear infusion are adequately described by a biexponential function.

(Des-tyrosine1)-gamma-endorphin in schizophrenia: clinical, biochemical, and hormonal aspects.

The neuropeptide (des-tyrosine1)-gamma-endorphin (DT gamma E; beta-LPH 62-77) was given to 10 schizophrenic patients who had been free of neuroleptic medication for at least 3 weeks. DT gamma E was injected intramuscularly in a dose of 1 mg daily for 10 days following a double-blind placebo-controlled crossover design. In 4 of the 10 patients a pronounced antipsychotic effect was observed; in 3 a temporary or slight reduction of psychotic symptoms occurred; and in 3 no response was noted.

Sibship with histidinemia and an unrelated encephalopathy. Clinical and biochemical studies.

Histidinemia was found in 3 of 4 siblings in one family, while a fatal encephalopathy with mental retardation was present in two of them and in the fourth child who did not have histidinemia. Biochemical studies of the histidinemic subjects showed elevated histidine levels in urine, CSF, and brain, while in a few urine samples histidine related imidazole compounds were found. Plasma levels of other amino acids were positively correlated with plasma histidine levels.

The vitamin B12-deficient rat as a possible model of ketotic hyperglycinemia.

The rate of oxidation to respiratory CO2 of both carbon 1 of propionate and carbon 1 of glycine was decreased significantly in vitamin B12-deficient rats, to 50% and 82% of the control rate, respectively. The activity of the glycine synthase system was reduced during vitamin B12 deficiency to 25% of control activity. Serine hydroxymethyltransferase activity was similar for vitamin B12-deficient and control rats.

Identification of N-acylglycines by gas-liquid chromatography.

Glycine conjugates of aliphatic carboxylic acids of clinical interest, and a series of structurally related compounds, were synthesized. The gas chromatographic elution behavior of trimethylsilyl derivatives of these N-acylglycines was examined on columns of 5% OV-1. A single peak for each compound was observed on the chromatograms after derivatization with a reagent containing N,9-bis-(trimethylsilyl)-acetamide in pyridine (1 : 1, v/v) for 20 min at 60 degrees C.

Urinary organic acid analysis in non-ketotic hyperglycinemia: non-specific occurrence of free benzoic acid, due to a beta-streptococcus infection.

The presence of free benzoic acid in the urine of a patient with non-ketotic hyperglycinemia was demonstrated to be due to a urinary tract infection with beta-streptococci (group B), and was eliminated by treatment with Penicillin G. In addition, the continuous excretion of p-hydroxyphenylacetic acid was observed. The patient was also found to excrete small and variable amounts of tiglic acid during the period of observation.