Publications by authors named "Gerrida M Uys"
Article Synopsis
- * Analysis of heart tissue from an infant with tetralogy of Fallot with pulmonary stenosis (ToF/PS) showed an increase in cardiomyocyte cytokinesis failure, linked to repression of the ECT2 gene due to β-adrenergic receptor activity.
- * Using β-blockers like propranolol was found to increase cardiomyocyte division, suggesting the potential for these drugs to help improve heart function and recovery in patients with ToF/PS and other forms of CHD.
Background: Cardiac contractility is regulated by dynamic phosphorylation of sarcomeric proteins by kinases such as cAMP-activated protein kinase A (PKA). Efficient phosphorylation requires that PKA be anchored close to its targets by A-kinase anchoring proteins (AKAPs). Cardiac Myosin Binding Protein-C (cMyBPC) and cardiac troponin I (cTNI) are hypertrophic cardiomyopathy (HCM)-causing sarcomeric proteins which regulate contractility in response to PKA phosphorylation.
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