[An association between microalbuminuria and obesity in healthy adolescents - preliminary results from the "Respect for Health" study].

Background: Microalbuminuria is a marker of present/future cardiovascular and/or renal disease. The roots of these diseases extend back into childhood. Data on renal excretion of albumin (albumin/creatinine ratio - ACR) and the prevalence of microalbuminuria in apparently healthy adolescents are scares.

Risk factors of cardiovascular diseases.

Background: Cardiovascular diseases are the leading cause of premature mortality of women and men in Slovak republic.

The Aim: The occurrence and mean values of major CVD risk factors were assessed in a population of 2480 Bratislava citizens (2/3 of them were women) interested in health promotion and primary CVD prevention activities in Community Health Promotion Center.

Methods: Major CVD risk factors were assessed, using standard methods, and criteria, in accordance with the guidelines of European and national medical societies.

The distribution of ciprofloxacin and its metabolites in human plasma, pulmonary and bronchial tissues.

The disposition of ciprofloxacin and its pharmacologically active metabolites (sulfociprofloxacin, oxociprofloxacin, and desethylenciprofloxacin) in plasma, lung and bronchial tissues was studied in 24 patients undergoing a partial or total resection of the lung. The patients were divided into four groups, a control group and groups in which ciprofloxacin (200 mg) was given i.v.

[Beta-aescin in the treatment of chronic venous insufficiency].

In 15 patients with primary or secondary chronic venous insufficiency (CHVI) the authors evaluated the action of three weeks' treatment with beta-aescin (Yellon caps). The regression of clinical symptoms of CHVI (sensation of "heavy" and "tired" legs, swollen ankles, nocturnal cramps was complete in five patients, partial or slight in seven patients, and none in three patients (with secondary venous insufficiency associated with thrombosis of the deep venous system). Undesirable effects of the agent were not revealed by common screening tests.

Protective effect of rioprostil on indomethacin-induced lesions of gastric and duodenal mucosa in healthy volunteers.

The protective effect of rioprostil against gastroduodenal mucosal lesions induced by indomethacin is investigated in a double-blind controlled trial on 36 healthy adult volunteers, divided into three groups. All the volunteers are treated with indomethacin, 50 mg t.d.

Comparison of the antihypertensive effects of celiprolol and acebutolol.

The antihypertensive effects of the new cardioselective beta-blocker celiprolol and acebutolol have been compared. Thirty patients with arterial hypertension WHO Grade I-II were treated in a double-blind fashion with celiprolol or acebutolol. Before starting the treatment and on Days 15 and 29, before the morning dose, blood samples were taken for measurement of the plasma level of celiprolol.

[Pharmacokinetics of the cephalosporin antibiotic cefotiam following its intravenous administration to patients after cholecystectomy].

The pharmacokinetic behaviour of cephalosporin antibiotic, second generation after intravenous administration to patients during the early post-operative period was characterized as well as after cholecystectomy. The data suggest a two-compartment distribution with elimination from the central compartment, realized on account of the renal way of clearance. In one of the patients, with one-compartment distribution of the drug, the presence of the theoretical determining factors in "the collapse" of one two-compartment open model to one-compartment is shown, associated with clinical characteristics of that patient.

Pharmacokinetics and quantitative characterization of cefotiam excretion after intravenous administration to patients after cholecystectomy.

Six patients, aged 52 to 71 years, with T-tube drainage of the common bile duct and a urinary catheter after cholecystectomy, were studied in order to evaluate the urinary and biliary excretion and pharmacokinetics of cefotiam in the early postoperative period. Each patient received cefotiam 1 g i.v.

[Characterization of the pathways of cefotiam elimination by clearance approaches in patients following cholecystectomy].

The clearance approach was used in the evaluation of the role of renal and biliary excretion in the total elimination of cephothiam from organism of patients after cholecystectomy. Six patients with inserted T-like drain into the choledochus duct and urinary catheter after gall bladder operation received I g cephothiam by stream intravenously during the early postoperative period. The value of renal clearance (= 132.

Plasma tryptophan level in chronic renal failure.

Total (Trp), free (fTrp) and bound (bTrp) tryptophan concentrations were measured in the plasma of hemodialyzed (HD), peritoneally dialyzed (CAPD) and conservatively treated (ND) patients in chronic renal failure (CRF). 1) A marked decrease of Trp and bTrp was found in all three groups of patients. 2) fTrp concentration was unaltered in the HD and CAPD groups but decreased in the ND patients.