Publications by authors named "Gero Teichmann"
Article Synopsis
- Cervical squamous cell carcinomas (CSCCs) linked to uterine prolapse show limited prior research, prompting a detailed study of their morphologic and molecular traits, including the identification of a new precursor lesion termed HPV-independent cervical intraepithelial neoplasia (CIN).
- The study involved four patients, primarily older women with advanced disease and TP53 mutations, none showing the common HPV DNA typically associated with cervical cancer.
- The precursor lesions displayed characteristics akin to differentiated vulvar intraepithelial lesions, suggesting a unique tumorigenetic pathway that differs from typical HPV-related processes.
Background: Radical hysterectomy based on empirical surgical anatomy to achieve a wide tumour resection is currently applied to treat early cervical cancer. Total mesometrial resection (TMMR) removes the embryologically defined uterovaginal (Müllerian) compartment except its distal part. Non-Müllerian paracervical and paravaginal tissues may remain in situ despite their possible close proximity to the tumour.
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