[Learning from Errors: Qualitative Analysis of Expert Reports on Malpractice in Family Medicine].

Background: Expert committees of the German medical associations provide a free and out-of-court evaluation of putative cases of medical malpractice. They prepare reports that contain valuable information on process steps that precede the actual treatment error. The aim of the present study was to identify and systematically categorize individual process steps in the expert reports and thus to lay the foundations for the understanding of malpractice evaluation processes.

Research tasks as part of the general practice clerkship in undergraduate medical education - a pilot project on feasibility and acceptance.

Objective: To assess the integration of a research task performed by students during their two-week clerkship in general practice.

Methods: Students were assigned to interview five patients with coronary heart disease using a standardised questionnaire focusing on potential interaction of medications with statins. Acceptance and feasibility was assessed by means of a questionnaire survey of teaching physicians (n = 20) and students (n = 20).

Students' performing of practical research tasks for their scientific qualification - an approach within the family practice internship in undergraduate education.

Background: Future physicians should be educated in evidence-based medicine. So it is of growing importance for medical students to acquire both practical medical and basic research competencies. However, possibilities and concepts focusing on the acquisition of basic practical research competencies during undergraduate medical studies in Germany are rare.

[The stable patient collective as a potential pitfall of prospective primary health-care studies. A qualitative inquiry among general practitioners].

Background And Purpose: Transparency and disclosure of problems in primary health-care studies can add enormous information to the planning and conduction of such studies. By means of the inquiry of study participants, important data on study problems can be found out. Therefore, the aim of this qualitative study was to identify the causes of unexpected results of an intervention study in general practitioners' (GPs) practices by means of an inquiry of the participating GPs.

[Factors associated with influenza vaccination information--a cross-sectional study in elderly primary care patients].

General practitioners (GPs) play an important role in influenza vaccination. However, reliable data on the influenza immunisation coverage rate in primary care patients are quite rare. Due to a lack of personal and time resources general practitioners cannot afford to collect such data by themselves.

Statin use and its association with musculoskeletal symptoms--a cross-sectional study in primary care settings.

Introduction: Musculoskeletal complaints are very common in primary care settings. Lipid-lowering drugs are one of several causes of musculoskeletal symptoms. However, data showing an association of lipid-lowering drug therapy and increased odds of musculoskeletal complaints in primary care patients are lacking.

Detection and management of alcohol use disorders in German primary care influenced by non-clinical factors.

Aims: The primary objective was to assess the proportion of detected and correctly referred patients in German primary care. The secondary objective was to identify patient and practitioner characteristics that predict detection and correct referral.

Methods: In this clustered cross-sectional survey in German primary care, 3003 patients were consecutively invited to participate, and were asked to fill in a standardized health questionnaire.

Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study.

Objective: Our objective was to study the impact of the cytochrome P450 (CYP) 2D6 polymorphism on the tolerability of metoprolol in a real-life primary care setting. The adverse effects studied comprised effects related to the central nervous system, cardiovascular effects, and sexual dysfunction.

Methods: Patients in whom treatment with metoprolol was considered were enrolled into this prospective, 6-week multicenter study.

[Rationale and methods of the UNAMET study (dose- and CYP2D6-genotype-dependent adverse drug reactions of metoprolol)--a contribution to quality improvement in pharmacotherapy].

Metoprolol has not yet been systematically studied in terms of quality of life and incidence of adverse drug reactions (ADRs). Metoprolol is metabolized by polymorphic CYP2D6, therefore poor CYP2D6 metabolizers may be at higher risk of ADRs. Therefore, it is to be proven whether genotyping is useful to guide initial dose selection.

[Quality of antithrombotic therapy in patients with chronic atrial fibrillation: the AFib Trial].

Background: Large randomised studies have definitely shown that oral anticoagulation effectively reduces thromboembolic complications, e.g. stroke, in patients with chronic non-valvular atrial fibrillation (AFib).