Publications by authors named "Germana Freire Rocha Caldas"
Article Synopsis
- The study explored the antiulcer effects of an ethanolic extract (SmEE) from a plant, as well as its main components, gallic acid (GA) and ellagic acid (EA), which are known for their medicinal properties.
- Various assays were conducted to determine the extract's antioxidant activity, revealing SmEE's ability to significantly reduce ulcer size in models induced by ethanol and non-steroidal anti-inflammatory drugs (NSAIDs).
- The findings indicate that not only does SmEE have protective effects on the gastric mucosa, but GA and EA also work together synergistically to enhance this protection against ulcers.
Contribution of Secondary Metabolites to the Gastroprotective Effect of Aqueous Extract of Ximenia americana L. (Olacaceae) Stem Bark in Rats.
Molecules
January 2018
L. (Olacaceae) is used in ethnomedicine as cicatrizant and for the treatment of gastric disorders. This study identified the chemical constituents of the aqueous extract of (XaAE) and evaluated its antiulcerogenic activity.
View Article and Find Full Text PDF1,8-cineole (eucalyptol) is widely used as an excipient in the pharmaceutical industry and as a food flavoring agent, thus providing significant potential for human exposure to the compound. We investigated the preclinical toxicity and reproductive toxicity of 1,8-cineole (CIN). In the repeated-doses toxicity study for 50 days, CIN (100, 500 or 1000 mg/kg) did not produce any signs of toxicity or deaths, but affected body weight gain during the first week of treatment.
View Article and Find Full Text PDFRecently, our research group identified and reported 1,8-cineole (CIN), a monoterpene that naturally occur in many aromatic plants, as one of the major constituent of the essential oil from leaves of Hyptis martiusii (EOHM), as well as characterized the gastroprotective action of this oil. The aim of this study was to investigate the mechanisms of action involved in the antiulcer and healing activity of CIN, in order to confirm its correlation with the gastroprotective effect of EOHM. Wistar rats were exposed to different protocols (acute ulceration, gastrointestinal motility and antisecretory activity).
View Article and Find Full Text PDFHyptis martiusii Benth. is an aromatic plant found in abundance in northeastern Brazil that is used in ethnomedicine to treat gastric disorders. The aim of this study was to elucidate the mechanisms of action involved in the gastroprotection of the essential oil of Hyptis martiusii (EOHM) and to evaluate its healing capacity.
View Article and Find Full Text PDFHyptis martiusii Benth. (Lamiaceae) is found in abundance in Northeastern Brazil where it is used in traditional medicine to treat gastric disorders. Since there are no studies reporting the toxicity and safety profile of this species, we investigated repeated-doses toxicity of the essential oil of Hyptis martiusii (EOHM).
View Article and Find Full Text PDFEthnopharmacological Relevance: Hyptis martiusii (Lamiaceae), popularly known as "cidreira-do-mato" or "cidreira-brava", grows in abundance in the Northeast region of Brazil, where its leaves are traditionally used in folk medicine in the treatment of intestinal and stomach diseases. The aim of this study was to characterize the chemical constituents and to evaluate the anti-ulcerogenic activity of the essential oil of the leaves of Hyptis martiusii (EOHM) in in vivo models of experimental ulcers in rodents.
Materials And Methods: EOHM was obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS).