A remifentanil/ketamine sedation in surgical cancer patients having severe Parkinson's disease: two case reports.

Symptoms of Parkinson's disease are related to a progressive loss of substancia nigra's dopaminergic neurons in addition to persistent activation of N-methyl-D-aspartate receptors. In specific situations such as sedation for minor surgery, tremor and dyskinesia can be very disabling. We report the beneficial effect of the combination of remifentanil (target-controlled infusion mode) and ketamine (boluses IV) to control dyskinesia and tremor for two elderly patients with Parkinson's disease.

The presence of amyloid in abdominal and oral mucosal tissues in patients initially diagnosed with multiple myeloma: a pilot study.

Objectives: The aims of this study were to (1) determine the feasibility of tandem assessment of the presence of amyloid in subcutaneous abdominal fat by fine-needle aspiration and oral mucosal tissue biopsy in patients initially diagnosed with multiple myeloma (MM) and (2) determine the optimal site for detection of amyloid in the oral cavity (tongue compared with labial minor salivary glands) in the same cohort of patients.

Study Design: A prospective, cross-sectional study was performed on patients with newly diagnosed MM. Subjects completed an abdominal fat pad aspirate and biopsies of both the tongue and labial minor salivary glands (LMSGs).

A 13-month multicenter clinical experience of a low-dose monophasic oral contraceptive containing 20 microg ethinylestradiol and 75 microg gestodene in Latin American women.

This prospective, multicenter study was conducted to evaluate the contraceptive reliability, cycle control and tolerability of a 21-day oral contraceptive regimen containing 20 microg ethinylestradiol and 75 microg gestodene in four Latin American countries (Mexico, Argentina, Brazil and Colombia). Participants took trial medication daily for 21 days. Contraceptive efficacy, cycle control and tolerability were evaluated over a period of 13 cycles.