Exploring the applicability of a lesion segmentation method on [F]fluorothymidine PET/CT images in diffuse large B-cell lymphoma.

Background And Purpose: The determination of the total metabolic tumour volume based on [F]fluorothymidine ([F]FLT) PET/CT images in diffuse large B-cell lymphoma has a potential clinical value for detecting early relapse in this type of heterogeneous lymphoproliferative tumours. Tumour segmentation is a key step in this process. For this purpose, our objective was to determine a segmentation threshold of [F]FLT PET/CT images, based on a reference tissue uptake, on a cohort of patients with diffuse large B-cell lymphoma (DLBCL) that have been scanned at different stages of the treatment.