Publications by authors named "German Gonzalez Santoyo"
Eur J Pharm Sci
October 2020
Article Synopsis
- Etanercept's complex glycosylation profile impacts its biological activity and stability, which was investigated through sequential deglycosylation.
- The study found that different glycans are crucial for Etanercept’s folding, with specific glycoforms significantly affecting antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and thermal stability.
- Removing sialic acids was particularly important for its surface charge and overall stability, highlighting the relevance of glycosylation in the function of this therapeutic protein.
