The study evaluated whether the way animals excrete a C-labeled drug predicts how humans do, focusing on urinary and fecal excretion in ADME studies.
A comparison of dosimetry input and output parameters showed no general correlation, but significant relationships emerged in specific studies based on ICRP guidelines.
Despite longer plasma half-lives of C in some human cases compared to predictions, the radiation burden remained within acceptable limits due to a controlled administration of C doses.