[The alignment of efficiency studies with clinical guidelines. Where are the opportunities for improvement?].

Objective: To provide insight as well as challenges and opportunities to more effectively align Dutch efficiency research with clinical guidelines.

Design: Evaluation research METHOD: The alignment with existing clinical guidelines regarding medical specialist care was analyzed for 111 efficiency studies funded by the Dutch national health care research programme, and completed between 2018-2023.

Results: Ninety percent of the studies could be linked to a clinical guideline.

Beta-adrenergic control of plasma glucose and free fatty acid levels in the air-breathing African catfish Clarias gariepinus Burchell 1822.

In several water-breathing fish species, beta-adrenergic receptor stimulation by noradrenaline leads to a decrease in plasma free fatty acid (FFA) levels, as opposed to an increase in air-breathing mammals. We hypothesised that this change in adrenergic control is related to the mode of breathing. Therefore, cannulated air-breathing African catfish were infused for 90 min with noradrenaline or with the nonselective beta-agonist, isoprenaline.

Beta-adrenoceptors mediate inhibition of lipolysis in adipocytes of tilapia (Oreochromis mossambicus).

The regulation of triglyceride mobilization by catecholamines was investigated in the teleost fish Oreochromis mossambicus (tilapia) in vivo and in vitro. In vitro experiments were carried out with adipocytes that were isolated for the first time from fish adipose tissue. For the in vivo experiments, cannulated tilapia were exposed to stepwise decreasing oxygen levels (20, 10, and 5% air saturation; 3.