Measurement of plasma protein and whole body protein metabolism using [N]glycine in a young adult man - a pilot study.

A novel simplified method is presented for the estimation of the metabolism of plasma proteins (albumin, fibrinogen, , and -globulin, glycoprotein) with regard to the whole body protein metabolism in a young male volunteer (22 years, 81 kg body mass). This method is based on multiple oral administration of [N]glycine followed by measurement of N in plasma proteins, total free amino acids, urea and excreted urinary N. The fractional synthesis rate of albumin was estimated to 6.