Publications by authors named "Gerhard Krajnik"
Article Synopsis
- Personalized medicine seeks to match specific cancer treatments to individual patients based on their tumor characteristics, but current methods only assist less than 10% of patients.
- A new approach, called single-cell functional precision medicine (scFPM), was tested on 143 patients with aggressive hematologic cancers, where 39% received treatments guided by scFPM results.
- Results showed that 54% of patients treated according to scFPM experienced improved progression-free survival, with some achieving exceptional responses lasting three times longer than typical, indicating the method's clinical feasibility and effectiveness.
Microarray-Based Detection of Allergen-Reactive IgE in Patients with Mastocytosis.
J Allergy Clin Immunol Pract
September 2020
Background: Because of a high risk to develop fatal anaphylaxis, early detection of immunoglobulin E (IgE)-dependent allergy is of particular importance in patients with mastocytosis.
Objective: We examined whether microarray-based screening for allergen-reactive IgE (allergen-chip) is a sensitive and robust approach to detect specific IgE in patients with mastocytosis.
Methods: Sera for 42 patients were analyzed, including 4 with cutaneous mastocytosis, 2 with mastocytosis in the skin, and 36 with systemic mastocytosis.
Induction chemotherapy may improve clinical outcome of locally advanced non-small cell lung cancer (NSCLC). To further pursue this, the Austrian Association for the Study of Lung Cancer (AASLC) performed a multi-center phase II trial with TIP induction chemotherapy (Taxol 175 mg/m2 over 3h on day 1, ifosfamide 1000 mg/m2 daily on days 1-3, cisplatin 60 mg/m2 on day 1, and prophylactic filgrastim 5 microg/kg daily on days 4-13). Treatment cycles were repeated every 3 weeks for 3 cycles.
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