Extranodal extension is a powerful prognostic factor in bladder cancer patients with lymph node metastasis.

Background: Lymph node metastasis (LNM) is the most powerful pathologic predictor of disease recurrence after radical cystectomy (RC). However, the outcomes of patients with LNM are highly variable.

Objective: To assess the prognostic value of extranodal extension (ENE) and other lymph node (LN) parameters.

Prognostic value of extranodal extension and other lymph node parameters in patients with upper tract urothelial carcinoma.

Purpose: We assessed the prognostic value of extranodal extension and other lymph node parameters in a large multicenter cohort of patients with lymph node metastasis after radical nephroureterectomy.

Materials And Methods: We retrospectively analyzed the records of 222 patients with lymph node metastasis treated with radical nephroureterectomy for upper tract urothelial carcinoma without neoadjuvant therapy. Each lymph node metastasis was microscopically evaluated for extranodal extension.