Publications by authors named "Gerhard C"

Objective: To document objective metrics of attenuation of the pulmonary parenchyma on inspiratory and expiratory breath-hold CT in dogs with bronchomalacia (BM) and dogs without BM (NoBM) using automated software analysis. Metrics included mean lung attenuation, percent low-attenuation area at -856 HU, percent high-attenuation area at -700 HU, and percent attenuation area between -600 and -250 HU.

Animals: Client-owned dogs with BM (n = 123) and NoBM (20).

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A 10-year-old male castrated Somali cat presented with neurologic signs, severe systemic hypertension, and hypokalemia. Abdominal ultrasonography demonstrated a left adrenal mass, and the serum aldosterone concentration was increased. Computed tomography and follow-up diagnostic testing confirmed a left adrenal mass consistent with functional adenocarcinoma; additional findings included chronic airway and parenchymal disease.

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Identifying immune modulators that impact neutralizing antibody responses against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is of great relevance. We postulated that high serum concentrations of soluble angiotensin-converting enzyme 2 (sACE2) might mask the spike and interfere with antibody maturation toward the SARS-CoV-2-receptor-binding motif (RBM). We tested 717 longitudinal samples from 295 COVID-19 patients and showed a 2- to 10-fold increase of enzymatically active sACE2 (a-sACE2), with up to 1 μg/mL total sACE2 in moderate and severe patients.

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Organic phase change materials (PCMs) are promising to utilize thermal energy from solar radiation for photothermal energy conversion. However, the issues of poor photo absorption and liquid leakage greatly restrict their practical application. Herein, a sustainable porous scaffold comprising periodate oxidized wood (POW) as the supporting material and in situ retains lignin as the light-absorber dopant are demonstrated.

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Article Synopsis
  • The design of antigens based on their structure could lead to more effective and safer vaccines by preventing negative interactions with host receptors.
  • The study introduces a methodology using deep mutational scanning to identify variations in the SARS-CoV-2 receptor binding domain that preserve immune response while avoiding interactions with host receptors.
  • The top variant identified, G502E, improved neutralizing antibody responses significantly and is part of a broader vaccine strategy called BIBAX that could enhance vaccine design for various pathogens.
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When exposing food and feedstuff to cold atmospheric pressure plasmas (CAPP), e.g., for decontamination purposes, possible unwanted effects on the contained nutrients might occur.

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A passive cooling strategy without any electricity input has shown a significant impact on overall energy consumption globally. However, designing tunable daytime radiative cooler to meet requirement of different weather conditions is still a big challenge, especially in hot, humid regions. Here, a novel type of tunable, thermally insulating and compressible cellulose nanocrystal (CNC) aerogel coolers is prepared via chemical cross-linking and unidirectional freeze casting process.

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Electrospun scaffolds can imitate the hierarchical structures present in the extracellular matrix, representing one of the main concerns of modern tissue engineering. They are characterized in order to evaluate their capability to support cells or to provide guidelines for reproducibility. The issues with widely used methods for morphological characterization are discussed in order to provide insight into a desirable methodology for electrospun scaffold characterization.

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Physical methods to control pest arthropods are increasing in importance, but detailed knowledge of the effects of some of these methods on the target organisms is lacking. The aim of this study was to use light sheet fluorescence microscopy (LSFM) in anatomical studies of blood-sucking arthropods in vivo to assess the suitability of this method to investigate the morphological structures of arthropods and changes in these structures over time, using the human louse Pediculus humanus (Phthiraptera: Pediculidae) as sample organism. Plasma treatment was used as an example of a procedure employed to control arthropods.

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Electrospun scaffolds have a 3D fibrous structure that attempts to imitate the extracellular matrix in order to be able to host cells. It has been reported in the literature that controlling fiber surface topography produces varying results regarding cell-scaffold interactions. This review analyzes the relevant literature concerning in vitro studies to provide a better understanding of the effect that controlling fiber surface topography has on cell-scaffold interactions.

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Hernia repair strengthens the abdominal wall with a textile mesh. Recurrence and pain indicate weak bonds between mesh and tissue. It remains a question which biomechanical factors strengthen the mesh-tissue interface, and whether surgeons can enhance the bond between mesh and tissue.

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Aspects of palliative medicine such as withholding and withdrawal of dialysis, initiating conservative therapy and cooperative end-of-life care have increasingly become part of standard renal care. The corresponding transfer of knowledge of palliative medicine principles has so far been lacking in training and further education. This consensus paper proposes structured curricular training for the kidney team based on principles of palliative care.

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Direct metal deposition (DMD) can be used for the cladding of surfaces as well as repairing and additive manufacturing of parts and features. Process monitoring and control methods ensure a consistent quality during manufacturing. Monitoring by optical emission spectroscopy of the process radiation can provide information on process conditions and the deposition layer.

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In 1850, Austen Henry Layard discovered an approximately 3000-year-old, simple optical lens in Nimrud, Northern Iraq-the Nimrud lens, aka the Layard lens [...

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Nanocomposites combine multiple favorable properties to achieve intriguing functionalities, but the formation of nanocomposites with only one constituent with the inclusion of multiple superior properties is still not known. Herein, novel self-compounded nanocomposite membranes from one single polymer-cellulose cinnamate (CCi)-with multiple outstanding properties are reported. The self-compounded membranes contain two distinct morphologies as CCi nanoparticles (CCi-NPs) and a CCi polymer matrix, while CCi-NPs are either firmly embedded in the CCi matrix or fused with adjacent CCi-NPs.

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The chemical composition of ground and polished fused silica glass surfaces plays a decisive role in different applications of optics. In particular, a high level of carbon impurities is often undesirable for further processing and especially for gluing or cementing where adhesion failure may be attributed to carbonic surface-adherent contaminants. In this study, the surface carbon content at different stages of classical optics manufacturing was thus investigated.

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Background: The diagnosis of residual or chronic elbow instability is often challenging. Sonography allows a dynamic examination of the elbow joint without any radiation exposure. The purpose of this prospective single-center study was to investigate the application of sonography for the evaluation of ligamentous instabilities of the elbow joint.

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One-dimensional nanomaterials including cellulose nanocrystals (CNCs) and gold nanorods (GNRs) are widely used in optical materials due to their respective inherent features: birefringence with accompanying light retardation and surface plasmon resonance (SPR). Herein, we successfully combine these properties of both nanorods to generate synergistic and readily tunable structural colors in hybrid composite polymer films. CNCs and GNRs are embedded either in the same or in separate films after unidirectional alignment in dynamic hydrogels.

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In this publication, it is shown how to synthesize silver nanoparticles from silver cations out of aqueous solutions by the use of an atmospheric pressure plasma source. The use of an atmospheric pressure plasma leads to a very fast reduction of silver ions in extensive solvent volumes. In order to investigate the nanoparticle synthesis process, ultraviolet/visible (UV/VIS) absorption spectra were recorded in situ.

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Cholecalciferol is becoming an increasingly utilized rodenticide in the United States due to changes implemented by the Environmental Protection Agency (EPA) to reduce unintended exposure of wildlife to second-generation anticoagulant rodenticides. The lipophilic properties of cholecalciferol and prolonged tissue elimination are well-documented; however, long-term clinical ramifications are unknown. This report describes unique clinicopathologic and treatment features during the acute phase of cholecalciferol rodenticide toxicosis in a 4-year-old neutered Shih-Tzu mix that presented for intermittent vomiting, anorexia, polyuria, and polydipsia.

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Aim: The goal of this retrospective cohort study was to analyze the relationship between induced abortion and the incidence of depression, anxiety disorder, adjustment disorder, and somatoform disorder in Germany.

Methods: Women who had undergone induced abortions for the first time in 281 gynecological practices in Germany between January 2007 and December 2016 were included (index date). Women with live births were matched (1:1) to those with induced abortion by age, index year, and physician.

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Aim: Our goal was to analyze the association between induced abortion, spontaneous abortion, and infertility respectively and the risk of psychiatric disorders in 57,770 women followed in gynecological practices in Germany.

Methods: This case-control study was based on data from the Disease Analyzer database (IQVIA). Women with a first documentation of depression, anxiety, adjustment disorder, or somatoform disorder in one of 281 gynecological practices in Germany between January 2013 and December 2017 were included in this study (index date).

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Laboratory plasmas inherently exhibit temperature and density gradients leading to complex investigations. We show that plasmas generated by laser ablation can constitute a robust exception to this. Supported by emission features not observed with other sources, we achieve plasmas of various compositions which are both uniform and in local thermodynamic equilibrium.

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We report on investigations of the spatial variations of contamination, roughness, and index of refraction of classically manufactured polished fused silica surfaces. Therefore, laser-induced breakdown spectroscopy was used to probe surface and subsurface impurities via the detection of aluminum. Measurements at different positions on the surface of the cylindrical fused silica windows evidenced an almost contamination-free center region, whereas a relatively large contamination area was found close to the edge.

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In this work, we investigated the generation of particles during pure laser and plasma-assisted laser ablation of titanium. Experiments were performed using a NIR picosecond laser at a wavelength of 1030 nm and a pulse duration of 8 ps. For plasma-assisted ablation, an atmospheric pressure dielectric barrier discharge plasma was applied where the process gas was argon.

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