Publications by authors named "Gergo Berke"
Article Synopsis
- * A review of nine randomized controlled trials (RCTs) involving 529 patients indicated no significant differences in mortality, anastomosis leakage, respiratory issues, or vomiting, though results regarding gastric emptying time (GET) presented mixed findings.
- * The study suggests that pyloric drainage is not essential in these operations, but emphasizes the need for further research, especially in European contexts, to draw more definitive conclusions.
Background: Chymotrypsin C (CTRC) protects the pancreas against unwanted intrapancreatic trypsin activity through degradation of trypsinogen. Loss-of-function CTRC variants increase the risk for chronic pancreatitis (CP). The aim of the present study was to characterize novel CTRC variants found during genetic testing of CP cases at a pediatric pancreatitis center.
View Article and Find Full Text PDFChymotrypsin C (CTRC) is a digestive serine protease produced by the pancreas that regulates intrapancreatic trypsin activity and provides a defensive mechanism against chronic pancreatitis (CP). CTRC exerts its protective effect by promoting degradation of trypsinogen, the precursor to trypsin. Loss-of-function missense and microdeletion variants of CTRC are found in around 4% of CP cases and increase disease risk by approximately 3-7-fold.
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- The study investigates the benefits of early oral feeding (EOF) versus late oral feeding after upper gastrointestinal surgeries for stomach and oesophageal cancer, focusing on recovery outcomes.
- Researchers reviewed 6 randomized control trials (RCTs) with 703 patients and found EOF led to faster recovery indicators like the appearance of gas and defecation, as well as shorter hospital stays.
- No significant difference in serious complications such as anastomosis leakage or infections was found between EOF and late feeding, suggesting EOF is safe and beneficial for patient recovery.
Introduction: Cystic fibrosis transmembrane conductance regulator (CFTR) plays a central role in pancreatic ductal fluid secretion by mediating Cl- and HCO3- ion transport across the apical membrane. Severe CFTR mutations that diminish chloride conductance cause cystic fibrosis (CF) if both alleles are affected, whereas heterozygous carrier status increases risk for chronic pancreatitis (CP). It has been proposed that a subset of CFTR variants characterized by a selective bicarbonate conductance defect (CFTRBD) may be associated with CP but not CF.
View Article and Find Full Text PDFThe digestive protease chymotrypsin C (CTRC) protects the pancreas against pancreatitis by degrading potentially harmful trypsinogen. Loss-of-function genetic variants in CTRC increase risk for chronic pancreatitis (CP) with variable effect size, as judged by the reported odds ratio (OR) values. Here, we performed a meta-analysis of published studies on four variants that alter the CTRC amino-acid sequence, are clinically relatively common (global carrier frequency in CP >1%), reproducibly showed association with CP and their loss of function phenotype was verified experimentally.
View Article and Find Full Text PDFThe calcium-sensing receptor (CASR) is expressed in the pancreas where it might regulate calcium concentrations in pancreatic secretions. Two independent studies reported conflicting results claiming that commonly occurring missense variants of the CASR gene are risk factors for chronic pancreatitis (CP). Here, we attempted to replicate the association between CASR variants and CP.
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