Therapeutic role of bone marrow mesenchymal stem cells in diabetic neuronal alternations of rat hippocampus.

Background: As the hippocampus is the main brain region for many forms of learning and memory functions and is acutely sensitive to blood glucose changes, diabetes mellitus, which is a serious metabolic disease, is often accompanied by learning and memory deficits. Through scientific literatures, mesenchymal stem cells (MSCs) promote functional recovery in rats with traumatic brain injury, so the present work was conducted to study MSCs as a possible treatment for the diabetic neuronal degeneration and functional impairment of rat hippocampus.

Materials And Methods: It was carried out using male albino rats: non-diabetic control groups (4, 8, 12 weeks) (n = 15), diabetic groups by i.

The comparative effects of sevoflurane and methohexital for electroconvulsive therapy.

The standard anesthetic agent for electroconvulsive therapy (ECT) has been methohexital. We compared sevoflurane, a short-acting halogenated anesthetic, to methohexital for induction in ECT. Twelve subjects received sevoflurane or methohexital on alternating treatment days.

Neuromuscular and cardiovascular effects of mivacurium chloride in surgical patients receiving nitrous oxide-narcotic or nitrous oxide-isoflurane anaesthesia.

The neuromuscular and cardiovascular effects of mivacurium chloride were studied during nitrous oxide-oxygen narcotic (fentanyl) (n = 90) and nitrous oxide-oxygen isoflurane (ISO) anaesthesia (n = 45). In addition, a separate group (n = 9) received succinylcholine during fentanyl anaesthesia to compare its neuromuscular effects with mivacurium. Mivacurium was initially administered as a single bolus in doses from 0.

Operating room management: the role of the anesthesiologist.

Operating room management structures and interrelationships both within the operating suite and with other departments in the hospital can be extremely complex. Several different professional and support groups are represented that often have infrastructures of their own that may compete or conflict with the operating room's management hierarchy. Often, there really is little actual management of the operating suite as an entity.

The neuromuscular blocking and cardiovascular effects of doxacurium chloride in patients receiving nitrous oxide narcotic anesthesia.

The purpose of this study was to evaluate neuromuscular and cardiovascular effects of doxacurium chloride, a new long-acting neuromuscular blocking agent, during a stable state of nitrous oxide and narcotic anesthesia. Ninety-three ASA physical status I or II patients were studied after informed written consent had been obtained. Eighty-one patients (group A) received doxacurium.

Accelerated onset of non-depolarizing neuromuscular blocking drugs: pancuronium, atracurium and vecuronium. A comparison with succinylcholine.

The time of onset and degree of neuromuscular blockade (NMB) in 80 anaesthetized patients, following either a single bolus injection of pancuronium 0.95 mg kg-1, atracurium 0.53 mg kg-1 or vecuronium 0.

Facilitation of rapid endotracheal intubations with divided doses of nondepolarizing neuromuscular blocking drugs.

The authors sought to determine whether prior administration of a small, subparalyzing dose of nondepolarizing muscle relaxant would shorten the onset time of an intubating dose of muscle relaxant. Initially, in 60 anesthetized patients, twitch response of adductor pollicis to ulnar nerve stimulation was studied after a small dose of pancuronium 0.015 mg .

Anesthesia and neuromuscular diseases.

This presentation presents a short review of some disease entities affecting the nuromuscular system. Most of these diseases are rare, but many have a direct implication for anesthetic management and the anesthesiologist should be aware of them and the interaction of the patient's disease and the physician's drugs.

The effects of d-tubocurarine, pancuronium and atracurium on the responses of gastrocnemius and soleus muscles in the cat.

In vivo, the effects of d-tubocurarine (0.20 mg kg-1), pancuronium (0.015 mg kg-1) and atracurium (0.

Effects of succinylcholine chloride on the response of fast and slow muscle in the cat.

Fast and slow muscle fibres differ histochemically, electrophysiologically and pharmacologically. In vivo, the effect of 0.05, 0.

Effects of venous air embolism on the cardiovascular system and acid base balance in the presence and absence of nitrous oxide.

Cardiovascular responses and acid-base changes with graded volumes of intravenously injected air were measured in dogs anesthesized with pentobarbital and either 100% oxygen or 50% oxygen and nitrous oxide. Mean arterial blood pressure decreased significantly with 2.5 ml of air/kg in the oxygen group and at all volumes in the nitrous oxide group.

Comparative effects of barbiturate or enflurane anesthesia with induced hypotension on intrapulmonary shunting.

Forty patients undergoing intracranial aneurysm clipping were operated on under either barbiturate anesthesia (in 22) or enflurane anesthesia (in 18). Cardiac output, arterial and mixed venous oxygen tension, and arterial, right atrial, pulmonary arterial, and pulmonary artery wedge pressures were measured. Cardiac index, intrapulmonary shunt fraction, and pulmonary vascular resistance were calculated.

Safety and efficacy of atracurium (BW33A) in surgical patients receiving balanced or isoflurane anesthesia.

Atracurium was administered in a dose range of 0.027-0.4 mg/kg and dose-response curves were established for both balanced and isoflurane anesthetic techniques.

Intubation conditions after atracurium and suxamethonium.

Conditions for endotracheal intubation provided by different dose regimens of atracurium 0.4 mg kg-1 and 0.5 mg kg-1 were studied and compared with each other and with suxamethonium 1.

Haemodynamic effects of atracurium in surgical patients under nitrous oxide, oxygen and isoflurane anaesthesia.

The haemodynamic effects of atracurium were studied in 16 patients (ASA I and II) undergoing major surgical procedures under nitrous oxide, oxygen and isoflurane anaesthesia. Atracurium was administered in two doses 0.2 and 0.

Comparative effects of etidocaine and lidocaine on nerve and neuromuscular conduction in the frog.

The effects of etidocaine and lidocaine were studied on frog nerve and neuromuscular junction. Etidocaine is 10 times more potent than lidocaine in blocking nerve conduction. At pH 6.

Hemodynamic effects of N2O, O2 barbiturate anesthesia and induced hypotension in early versus late aneurysm clipping.

The cardiovascular effects of large dose thiopental anesthesia and induced hypotension were examined in 22 patients undergoing clipping of ruptured intracranial aneurysms. Eleven patients operated on within 4 days of the initial bleed (early group) were compared with those operated on more than 10 days after the bleed (late group). Systemic and pulmonary arterial pressures, central venous pressure, and cardiac output were measured.

Effect of spinal cord transection on neuromuscular function in the rat.

The effect of T6 spinal cord transection on neuromuscular physiology, pharmacology, and histochemistry as well as succinylcholine-induced changes in serum potassium were studied in 88 Sprague-Dawley rats and compared to 19 control animals. Resting membrane potential of spinal cord transected animals decreased by a maximum of 15 mV. This change was significant at days 3, 7, and 30 posttransection.