[The mechanisms of the effect of serotonin on the prostacyclin synthesis and coronary vascular resistance of the isolated rat heart].

An early reduction of coronary vascular resistance after serotonin administration was found to be due to the activity of prostacyclin synthesis and an endothelial-relaxing factor in the rat isolated heart. The activating effect of serotonin on the prostacyclin synthesis was inhibited by catanserin and dyltyasem. The latters prevented damage of endotheliocytes and the beginning of a vasal constriction caused by the protracted serotonin action.

[The cholesterol and lysophospholipid content of the plasma and blood cells in patients with stable stenocardia of effort].

A study of 13 patients with stable exertion stenocardia and a positive bicycle ergometry [correction of veloergometric] test revealed an activation of the thrombocytic lysoform factors (lyso-FAT) along with reduction of cholesterol lipoproteids of density activity of lecithincholesterolacyltranferase. Increase of lyso-FAT is associated with accumulation of cholesterol and lysophosphatidylcholine in thrombocytes and erythrocytes. The participation of lyso-FAT in the pathogenesis of stable exertion stenocardia is suggested.

[The use of finoptin and alpha-tocopherol in patients with stable exertional stenocardia].

A study of 59 patients of stable exertion stenocardia (functional class III) revealed an increased content of lipid hydroperoxide in lipoproteids of low and very low density that was associated with an increased level of malonic dialdehyde in of their functional activity, in particular, during physical loads. Finoptin monotherapy did not effect essentially the level of hydroperoxides in lipoproteids of low density, malonic dialdehyde in thrombocytes. Combination of finoptin and alpha-tocopherol reduced essentially the processes of lipid peroxidation, reducing, thus, the functional activity of thrombocytes at rest and loads.

[The effect of ultrasonic oscillations of different frequencies on radionuclide accumulation in the eye tissues].

The paper describes results of experimental investigations in 25 rabbits for the purpose to study permeability of eye tissues under the action of ultrasound of different frequencies (127, 295, 470, 660, 880, 1000, 2750 kHz). The following radioactive nuclides were used: 99mTc--pertechnetate, 125I in a form of KI and 45CaCl2. In investigations with 99mTc--pertechnetate and 45CaCl2, their accumulation in the aqueous humor, vitreous body, cornea, iris, sclera, crystalline lens, choroid and retina was studied.

[Effect of alpha-tocopherol combined with finoptin on the level of lipid hydroperoxides in plasma lipoproteins and on the functional activity of thrombocytes in patients with exertion-induced stable stenocardia].

Thirty three patients with stable effort-associated angina (Functional Class II) were examined. Enhanced lipid hydroperoxide levels in plasma lipids from the patients were found to play a pathogenetic role in the disturbance of platelet microcirculatory homeostasis. The calcium antagonist finoptin used in combination with alpha-tocopherol made it possible to decrease lipid hydroperoxide levels in low density lipoproteins and malondialdehyde concentrations in platelets, to prevent abnormal cyclic nucleotide metabolism in them and to increase tolerance to physical exercise.

[The use of potassium-magnesium-sodium chloride-sulfate mineral water and direct current (experimental research)].

To evaluate a therapeutic potential of a test treatment of chronic hepatitis with mineral water followed by hepatic galvanization, the authors have conducted an experimental study on 38 rats. The animals were divided into 4 experimental and 4 control groups. Experimental animals of groups 1 and 2 underwent galvanization of the liver 1 hour after the intake of mineral water in combination with 22Na-labelled sodium chloride, of group 3 in combination with 35S-labelled sodium sulfate, of group 4--with labelled rubidium.

[Decrease in cAMP levels and increase in cGMP levels in the small intestine mucosa after treatment with fluoride].

Sodium fluoride was studied for its effect on the cAMP and cGMP amount in the small intestine mucosa of rats under conditions of acute and chronic experiments. A significant decrease in the cAMP level and an increase in the cGMP level were revealed in both cases. Changes in the content of cyclic nucleotides were followed by marked changes in their physiologically important ratios.

[Spermatogenesis in varicoceles after correction of the blood supply to the testis].

By means of light microscopy methods in experiments performed in 60 white rats with modelled venous congestion in the left testis and in 113 men suffering from varicocele of the 2d-3d degree complicated with certain disorders of fertility, the effect of blood correction has been studied in the gonads by switching off the caudal (inferior) epigastric vein. The experimental correction of the blood stream in the testes, according to the data of quantitative estimations, contributes to spermatogenesis. Corresponding positive results, while studying spermograms, are obtained in patients suffering from varicocele complicated with infertility.

[Effect of natriuretic factor on sodium secretion in the small intestine].

In dogs with Tiri-Vella fistula, the natriuretic factor increases the secretion of the intestinal fluid and its content of sodium. In rats with increased content of natriuretic factor, the water and sodium absorption diminishes in the intestine whereas the secretion of 22Na into the intestine lumen is increased.

[Effect of adrenaline administration on the interrelation between free fatty acid concentration in the blood and platelet accumulation in the circulatory bed of the myocardium].

Experiments on rabbits were made to specify the role of free fatty acids (FFA) in the platelet accumulation in the blood vessels of the myocardium during adrenaline administration. The lipolytic effect of adrenaline was modified by administering heparin or nicotinic acid. The platelet accumulation was evaluated from electron microscopy findings and from the change in the content of autologous platelets labeled with 51Cr.

[Effect of hydrocortisone on mobilization and restoration of glycogen depot in the myocardium].

The mechanism of glycogen content changes in the heart muscle was studied in rat experiments by radio-isotope techniques 30, 60 min. and 3 hours following hydrocortisone administration. It was found that early after hydrocortisone administration (30 min.

[The effect of extracardiac nerves on the intensity of glycogen metabolism in cardiac muscle].

The left vagus was cut in rats on the neck; this was followed by a reduction of the glycogen content in the myocardium and by an increase in the intensity of its metabolism (by the glucose-I-C14 incorporation). Sympathetic denervation of the heart led to the increase in the glycogen level and a fall of the intensity of its metabolism in the cardiac muscle.