Ammonium Polyuranates: Old Dog, New Structural Tricks.

The crystal structure of ammonium polyuranates has been investigated. Powder X-ray diffraction (PXRD) has been employed to define single-phase samples within a series of synthesized compounds, which are further characterized by elemental analysis to ascertain the stoichiometry, revealing compositions of and . Analysis using extended X-ray absorption fine structure and vibrational spectroscopy has elucidated that both and possess a local structure similar to the metaschoepite─layered U(VI) oxohydroxide UO·2HO, but with HO and NH groups in the interlayers.

Sensory reweighting of postural control requires distinct rambling and trembling sway adaptations.

Background: Implementation of the Sensory Organization Test (SOT) under the rambling-trembling (RM-TR) framework allows for an examination of both individual sensory contributions and compensatory mechanisms, a valuable insight in research and clinical settings. Such investigation could substantially improve our ability to assess and treat fall risk in older adults and people living with neurological disorders.

Research Question: How are RM and TR components of sway influenced by SOT-induced challenges in healthy adults?

Methods: Twenty-three healthy adults (27.

SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity.

SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memory, and cognition. Mutations in in humans result in intellectual disability, autistic-like behaviors, and epilepsy. Heterozygous -knockout mice display deficits in synaptic plasticity, learning, and memory and exhibit seizures.

Feasibility of an Application-Based Outpatient Rehabilitation Program for Stroke Survivors: Acceptability and Preliminary Results for Patient-Reported Outcomes.

Background: The majority of stroke survivors experience long-term impairments. Regular physical activity and other lifestyle modifications play an important role in rehabilitation. Outpatient rehabilitation using telemedicine might be suitable to improve functional ability and long-term secondary prevention.

High-throughput ab initio design of atomic interfaces using InterMatch.

Forming a hetero-interface is a materials-design strategy that can access an astronomically large phase space. However, the immense phase space necessitates a high-throughput approach for an optimal interface design. Here we introduce a high-throughput computational framework, InterMatch, for efficiently predicting charge transfer, strain, and superlattice structure of an interface by leveraging the databases of individual bulk materials.

Laboratory-based X-ray spectrometer for actinide science.

X-ray absorption and emission spectroscopies nowadays are advanced characterization methods for fundamental and applied actinide research. One of the advantages of these methods is to reveal slight changes in the structural and electronic properties of radionuclides. The experiments are generally carried out at synchrotrons.

Mouse models of -related intellectual disability.

SYNGAP1 is a Ras-GTPase-activating protein highly enriched at excitatory synapses in the brain. De novo loss-of-function mutations in are a major cause of genetically defined neurodevelopmental disorders (NDDs). These mutations are highly penetrant and cause -related intellectual disability (SRID), an NDD characterized by cognitive impairment, social deficits, early-onset seizures, and sleep disturbances.

From worst-case to reality - Case studies illustrating tiered refinement of consumer exposure to cosmetic ingredients.

Consumer exposure to cosmetic ingredients is estimated in a tiered manner. Simple Tier1 deterministic aggregate exposure modelling generates a worst case estimate of exposure. Tier1 assumes that a consumer uses all cosmetic products concomitantly daily, at maximum frequency, and products always contain the ingredient at the maximum allowed % w/w concentration.

Distinct ventral stream and prefrontal cortex representational dynamics during sustained conscious visual perception.

Instances of sustained stationary sensory input are ubiquitous. However, previous work focused almost exclusively on transient onset responses. This presents a critical challenge for neural theories of consciousness, which should account for the full temporal extent of experience.

Subthreshold white noise vibration alters trembling sway in older adults.

Background: Somatosensory deficit is a significant contributor to falls in older adults. Stochastic resonance has shown promise in recent studies of somatosensation-based balance disorders, improving many measures of stability both inside and outside of the clinic. However, our understanding of this effect from a physiological perspective is poorly understood.

Mouse models of -related intellectual disability.

Unlabelled: SYNGAP1 is a Ras-GTPase activating protein highly enriched at excitatory synapses in the brain. loss-of-function mutations in are a major cause of genetically defined neurodevelopmental disorders (NDD). These mutations are highly penetrant and cause -related intellectual disability (SRID), a NDD characterized by cognitive impairment, social deficits, early-onset seizures, and sleep disturbances (1-5).

The Application of an Extracellular Vesicle-Based Biosensor in Early Diagnosis and Prediction of Chemoresponsiveness in Ovarian Cancer.

Background: Ovarian cancer (OVCA) is the most fatal gynecological cancer with late diagnosis and plasma gelsolin (pGSN)-mediated chemoresistance representing the main obstacles to treatment success. Since there is no reliable approach to diagnosing patients at an early stage as well as predicting chemoresponsiveness, there is an urgent need to develop a diagnostic platform for such purposes. Small extracellular vesicles (sEVs) are attractive biomarkers given their potential accuracy for targeting tumor sites.

Domain-Dependent Surface Adhesion in Twisted Few-Layer Graphene: Platform for Moiré-Assisted Chemistry.

Twisted van der Waals multilayers are widely regarded as a rich platform to access novel electronic phases thanks to the multiple degrees of freedom available for controlling their electronic and chemical properties. Here, we propose that the stacking domains that form naturally due to the relative twist between successive layers act as an additional "knob" for controlling the behavior of these systems and report the emergence and engineering of stacking domain-dependent surface chemistry in twisted few-layer graphene. Using mid-infrared near-field optical microscopy and atomic force microscopy, we observe a selective adhesion of metallic nanoparticles and liquid water at the domains with rhombohedral stacking configurations of minimally twisted double bi- and trilayer graphene.

Predicting chemoresponsiveness in epithelial ovarian cancer patients using circulating small extracellular vesicle-derived plasma gelsolin.

Background: Resistance to chemotherapy continues to be a challenge when treating epithelial ovarian cancer (EOC), contributing to low patient survival rates. While CA125, the conventional EOC biomarker, has been useful in monitoring patients' response to therapy, there are no biomarkers used to predict treatment response prior to chemotherapy. Previous work in vitro showed that plasma gelsolin (pGSN) is highly expressed in chemoresistant EOC cell lines, where it is secreted in small extracellular vesicles (sEVs).

A QBO Cookbook: Sensitivity of the Quasi-Biennial Oscillation to Resolution, Resolved Waves, and Parameterized Gravity Waves.

An intermediate complexity moist general circulation model is used to investigate the sensitivity of the quasi-biennial oscillation (QBO) to resolution, diffusion, tropical tropospheric waves, and parameterized gravity waves. Finer horizontal resolution is shown to lead to a shorter period, while finer vertical resolution is shown to lead to a longer period and to a larger amplitude in the lowermost stratosphere. More scale-selective diffusion leads to a faster and stronger QBO, while enhancing the sources of tropospheric stationary wave activity leads to a weaker QBO.

To form or not to form: PuO nanoparticles at acidic pH.

The aim of this study is to synthesize PuO nanoparticles (NPs) at low pH values and characterize the materials using laboratory and synchrotron-based methods. Properties of the PuO NPs formed under acidic conditions (pH 1-4) are explored here at the atomic scale. High-resolution transmission electron microscopy (HRTEM) is applied to characterize the crystallinity, morphology and size of the particles.

Strong interlayer interactions in bilayer and trilayer moiré superlattices.

Moiré superlattices constructed from transition metal dichalcogenides have demonstrated a series of emergent phenomena, including moiré excitons, flat bands, and correlated insulating states. All of these phenomena depend crucially on the presence of strong moiré potentials, yet the properties of these moiré potentials, and the mechanisms by which they can be generated, remain largely open questions. Here, we use angle-resolved photoemission spectroscopy with submicron spatial resolution to investigate an aligned WS/WSe moiré superlattice and graphene/WS/WSe trilayer heterostructure.

The Promise and Challenge of Integrating Multidisciplinary and Civically Engaged Learning.

Today's students need to become specialists in their profession while also recognizing the blinders that specialization brings- they need both disciplinary and meta-disciplinary learning. Today's universities need to innovate by providing an education responsive to contemporary demands. They also need to show their relevance to the broader publics they serve.

Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.

Type 2 diabetes is associated with insulin resistance, impaired pancreatic β-cell insulin secretion, and nonalcoholic fatty liver disease. Tissue-specific SWELL1 ablation impairs insulin signaling in adipose, skeletal muscle, and endothelium, and impairs β-cell insulin secretion and glycemic control. Here, we show that I and SWELL1 protein are reduced in adipose and β-cells in murine and human diabetes.

Rambling-trembling center-of-pressure decomposition reveals distinct sway responses to simulated somatosensory deficit.

Background: Falls in older adults are often multifactorial, but can be linked to diminished sensation capabilities from age-related neural degeneration. Rambling-trembling (RM-TR) decomposition may provide insight into the relation between sensorineural function and postural sway, with both research and clinical applications.

Research Question: What are the effects of perturbed somatosensation on RM-TR-derived measures of center of pressure (COP) during quiet standing?

Methods: Fifty-two healthy young adults (22.

HIV-antiretrovirals in river water from Gauteng, South Africa: Mixed messages of wastewater inflows as source.

South Africa has the highest number of people living with the human immunodeficiency virus (HIV). High usage of HIV-antiretroviral drugs (ARVs) for the treatment of the acquired immunodeficiency syndrome (AIDS) leads to the presence of ARVs in the environment. Wastewater is a major contributor of pharmaceuticals in surface and drinking water as wastewater treatment plants (WWTPs) are not designed to remove these compounds.

Increasing incidence and risk factors for divergence insufficiency esotropia.

Purpose: To document the increasing incidence of divergence insufficiency (DI) esotropia and to identify risk factors for DI.

Methods: All patients with a diagnosis of esotropia seen by one provider (DLG) over 41 years were identified from the medical record. Patients with onset of strabismus before age 10 years or with prior strabismus surgery were excluded.

Health-Related Social Needs Among Emergency Department Patients with HIV.

Little research has examined the health-related social needs of emergency department (ED) patients who have HIV. We surveyed a random sample of public hospital ED patients and compared the social needs of patients with and without HIV. Social needs were high among all ED patients, but patients with HIV reported significantly higher levels of food insecurity (65.