The HLA-B*38:110 allele identified in a volunteer bone marrow donor.

HLA-B*38:110 allele differs from HLA-B*38:01:01:01 in codon 202 in exon 4.

[Association of the Level of Serum Prolactin with Polymorphic Variants of the GRIN2A, GPM3, and GPM7 Genes in Patients with Schizophrenia Taking Conventional and Atypical Antipsychotics].

The dopamine, serotonin and glutamate systems are jointly involved in the pathogenesis and pharmacotherapy of schizophrenia. We formulated a hypothesis that polymorphic variants of the GRIN2A, GRM3, and GRM7 genes may be associated with the development of hyperprolactinemia in patients with schizophrenia taking conventional and atypical antipsychotics as basic treatment. 432 Caucasian patients diagnosed with schizophrenia were examined.

Comparative Characteristics of the Metabolic Syndrome Prevalence in Patients With Schizophrenia in Three Western Siberia Psychiatric Hospitals.

The purpose of this study was to compare the prevalence of MetS and the associated sociodemographic, clinical, and pharmacotherapeutic characteristics of patients with schizophrenia in three psychiatric hospitals in the West Siberian region. Patients with a clinical diagnosis of schizophrenia (ICD-10: F20) and an age between 18 and 60 years were included in the study after giving informed consent. Metabolic syndrome was diagnosed according to the International Diabetes Federation criteria.

Cytokine Level Changes in Schizophrenia Patients with and without Metabolic Syndrome Treated with Atypical Antipsychotics.

The present study aims at comparing the change in cytokine levels in schizophrenia patients treated with atypical antipsychotics, with or without metabolic syndrome (MetS). The study included 101 patients with schizophrenia, 38 with and 63 without MetS, who received risperidone, quetiapine, olanzapine or aripiprazole for six weeks. We analyzed the concentration of 21 cytokines in the serum patients.

[The status of large vessels in overweight and obesity according to ultrasound findings].

Aim: To investigate the impact of overweight and obesity on the structure and function of large arteries in apparently healthy individuals; to estimate the magnitude of atherosclerotic lesions of the vessels.

Materials And Methods: Sixty-one apparently healthy individuals with varying weights were randomly examined. All the examinees were divided into 3 groups according to their body mass index (BMI) and blood pressure (BP).

EPIDEMIOLOGICAL FEATURES OF CHRONIC VIRUS HEPATITIS B AND C IN THE REPUBLIC SAKHA (YAKUTIA).

High disease burden of chronic virus hepatitis B and C of population in the Republic Sakha (Yakutia) is subject to referring it to endemic territories due to these infections. For a 15-year-old period the disease has been registered at higher rates in the Russian Federation.

[Molecular epidemiology of hepatitis C in centers of hemodialysis in St. Petersburg].

Aim: Study molecular epidemiology of hepatitis C (HC) in 5 departments of hemodialysis (DH) in St. Petersburg.

Materials And Methods: Sequences of nucleotides of 93 isolates including 67 isolates from patents of 5 DH and 26 isolates from patients, who never had hemodialysis in anamnesis, were obtained in 2010 by a method of limited sequencing of NS5B region of HC virus genome.

Heterodinuclear (Sm, Tb) lanthanide pivalates with heterocyclic N-donors: synthesis, structure, thermal behavior, and magnetic and photoluminescence properties.

Heterobimetallic complexes [SmTb(piv)6(phen)2] (1), [SmTb(piv)6(bath)2]·1.75EtOH (2a·1.75EtOH), [SmTb(piv)6(bath)2]·2EtOH (2b·2EtOH), and [SmTb(piv)6(bath)2]·EtOH (2b·EtOH), where piv is (CH3)3CCO2(-), phen is 1,10-phenanthroline, and bath is 4,7-diphenyl-1,10-phenanthroline, were synthesized and studied by X-ray diffraction.

[Assessment of clinical-instrumental, morphological data and expression of coxsackie adenovirus receptor in patients with inflammatory cardiac pathology].

In 22 patients with heart failure and/or ventricular arrhythmias presumably of inflammatory etiology the results of clinical and instrumental investigation were analyzed and compared to the endomyocardial biopsy data. In the subgroup of patients with left bundle branch block (LBBB) we revealed features indicative of lesser contribution of inflammatory destruction in pathogenesis of cardiomyopathy. The only virus, detected in biopsy samples, was parvovirus B19.

[Use of functional classes to assess the status of patients with severe heart failure].

The possibilities of the classification developed by Lang, Strazhesko, Vasilenko and that of heart failure functional classes, which has been adopted by the New York Heart Association (NYHA), to evaluate the status of patients with severe heart failure are compared in this communication. A total of 1619 patients with Stages IIB-III heart failure of various origin (coronary heart disease, dilated cardiomyopathy, rheumatic heart disease, myocarditis, primary pulmonary hypertension) were studied. To assess the patients' status the attending physicians used 7 grades: (1) satisfactory; (2) close to moderate; (3) moderate; (4) close to severe; (5) severe; (6) close to critical; (7) critical.

Growth of replicating DNA chain in adult and old rat spleen.

The rate of growth of the DNA chain length was found to decrease in rat spleen with aging. This can be substantiated by the slowing down of transformation of old spleen 3H-labeled DNA with low molecular weight to that with high molecular weight as labeling time increases. At the same time, the intensity of the DNA total synthesis is higher in old spleens than in adult ones.

[State of DNA structural alkalinity in tissue of rats of different ages].

The single-strand breaks in DNA of cell nuclei of the normal and regenerating liver and kidneys are studied depending on the rat age by the sedimentation analysis within the gradient of alkaline sucrose without previous purification and isolation of the preparations. It is found that DNA of tissues under study in the six-month rats sedimentates, forming one fraction of high-molecular DNA (molecular mass 1.3-1.

[Relationship between tissue mitotic activity, animal age and defects in the secondary structure of DNA].

The content of defects of the secondary structure of DNA native and gamma-irradiated preparations from the intestinal mucosa and liver of adult (6-8 months) and old (24-26 months) rats was studied by the kinetic formaldehyde method. The content of the native DNA secondary structure defects does not depend on the animal and tissue mitotic activity. After gamma-irradiation in vitro (60Co, 550 R/min, 3 and 6 krad) of intestinal mucosa DNA solutions (tissues with a high mitotic activity) the content of the DNA defects is higher in old animals than in young ones.

[Comparative characteristics of the methods of management of the pleural cavity in nonspecific empyema].

The author failed to reveal some essential advantages of any of five methods employed for sanation of the pleural cavity in empyema. The method of active aspiration and irrigation of the cavity with antiseptic and antibiotic solutions is felt to be mostly rational.