Genome Analysis of the Probiotic Strain Enterococcus faecium Ef79OSAU.

We report here the draft genome sequence of Enterococcus faecium strain Ef79OSAU, which was isolated from swine feces. The characteristics of strain Ef79OSAU reveal the absence of pathogenicity factors, a wide range of antimicrobial activity , and antilisteriosis activity . Analysis of the E.

Regulation of the radionuclide content in commodities produced in areas affected by the Chornobyl accident.

This paper discusses the approaches to regulation of the content of radionuclides in commodities and compares the international and Ukrainian standards, which establish permissible levels of the content of radionuclides in food-stuffs produced in the Chornobyl-affected areas. The paper gives the actual monitoring data and discusses the main causes of differences between Ukrainian, European and international standards. The need for improvement of current approaches to the regulation of the content of radionuclides in commodities is highlighted.

[Medical and psychological prediction of professional readiness of graduates of military school].

The authors propose a method for assessing the professional readiness of graduates of military educational institution, taking into account academic performance, the results of sociometric surveys, data on the professional fitness and health. The high efficiency of the developed method for predicting successful adaptation of graduates to serve in the armed forces is showed.

Comment on "Equivalence of two approaches for quantum-classical hybrid systems" [J. Chem. Phys. 128, 204104 (2008)].

We discuss the links between consistent and approximate descriptions of the quantum-classical systems, i.e., systems composed of two interacting subsystems, one of which behaves almost classically while the other requires a quantum description.

[Gene pool of pig breeds in southern region of Ukraine as determined from immunogenetic parameters].

On the basis of the long-term observations of 22 334 pedigree animals, the level of genetic polymorphism and basic breed-specific immunogenetic parameters were determined in eight major pig breeds from southern Ukraine. The high level of gene diversity was revealed and the degree of genetic similarity between the studied breeds was estimated.

[Immunogenetic structure of the Ukrainian White Steppe species pig herd by frequency of complex genotypes in connection with some parameters of productivity].

Studying of the structural organization of the gene pool considering frequencies of occurrence of complex genotypes in animals simultaneously by many loci of blood groups allows to better characterize immunogenetic parameters of populations and peculiarities of selection acting upon animals of different genetic classes. The data on presence of the optimum level of gene diversity and peculiarities of selection acting upon polymorphic systems of blood groups in the pig herd of Ukrainian Steppe White breed have been obtained. The results can be used for increasing efficiency of breeding.

SLIPPER-2001 -- software for predicting molecular properties on the basis of physicochemical descriptors and structural similarity.

A new approach for predicting the lipophilicity (log P), solubility (log Sw), and oral absorption of drugs in humans (FA) is described. It is based on structural and physicochemical similarity and is realized in the software program SLIPPER-2001. Calculated and experimental values of log P, log Sw, and FA for 42 drugs were used to demonstrate the predictive power of the program.

New diversity calculations algorithms used for compound selection.

Some modifications were introduced into the previously described Centroid diversity sorting algorithm, which uses cosine similarity metric. The modified algorithm is suitable for the work with large databases on personal computers. For example, for diversity sorting of the database with the size greater than a million of records, less than 9 h are required (Pentium III, 800 MHz).

[Structural organization of the gene pool of the Ukrainian steppe white pig breed from immunogenetic markers].

The study of structural organization of gene pool was conducted for eight blood-group genetic systems (transferrin, haptoglobin, and amilase) in three stock herds of pigs of the Ukrainskaya Stepnaya Belaya breed that were bred under the conditions of southern Ukraine. Typical gene combinations (complex genotypes) of this breed were detected, and the main breed-specific parameters of distribution of genetic markers were described.

[Comparative study of the role of cytokines in various eye diseases. 2. Diabetic retinopathy].

The role of cytokines in the pathogenesis of diabetic retinopathy and mechanism of action of laser coagulation of the retina were investigated. A total of 110 patients with insulin-dependent diabetes mellitus without clinical signs of diabetic retinopathy and at various stages of its development (subclinical, manifest preproliferative, and proliferative) were observed. Twenty-four of them were subjected to laser coagulation of the retina and/or vitrectomy.

[One-stage reconstruction of the breast after mastectomy with skin preservation].

Our experience points to the advantages of preserving a cutaneous flap remaining after mastectomy followed by one-stage reconstruction using a recto-abdominal flap of silicone expanders and endoprostheses. The procedures used provided for removal of the halo-papillary complex, skin scarred by biopsy, the entire mammary gland tissue with the subaxillary, subclavicular and subscapular lymph nodes. The epithelium was removed from the recto-abdominal flap which was placed into a cutaneous pouch after mastectomy.

[Comparative study of the role of cytokines in different forms of eye diseases. 1. Tumor necrosis factor-alpha].

Local and total-systems production of tumor necrosis factor-alpha (TNF) is studied in 214 patients with different clinical forms of inflammatory and other than inflammatory diseases of the eyes. Healthy donors were controls. A total of 265 blood sera, 335 lacrimal fluid samples, and 9 specimens of subretinal fluid were examined.

[Interleukin-6 in patients with uveal melanoma].

Studies of the blood serum and tears of patients with uveal melanoma revealed local (14.3%) and total-systems (11.1%) production of interleukin-6 (IL-6).

Radiation-induced chromosome damage in astronauts' lymphocytes.

The increased number of manned space missions has made it important to estimate the biological risks encountered by astronauts. As they are exposed to cosmic rays, especially ions with high linear energy transfer (LET), it is necessary to estimate the doses they receive. The most sensitive biological dosimetry used is based on the quantification of radiation-induced chromosome damage to human lymphocytes.

[Chromosome aberrations in peripheral blood lymphocytes of cosmonauts after long-term space flight].

The incidence and the types of chromosome aberrations in lymphocytes of the peripheral blood in culture in vivo were studied in a cosmonaut following 14-day space flight (SF) and in three cosmonauts on completion of 177- and 194-day SF. After prolonged SF each cosmonaut displayed an increase in the number of aberrant cells and the incidence of chromosome damages. The rise in the number of aberrant cells was 2-3-fold comparing with the preflight level and 3-8-fold comparing with the number of aberrant mitoses in young subjects.

Effects of sublethal irradiation with helium ions (300 MeV/nucleon) on basic hematological parameters of mice.

The aim of the experiment was to obtain new knowledge on the biological effectiveness of high-energy (300 MeV/nucleon) helium ions, which represent a part of the spectrum of cosmic rays. Male (CBA x C57BL)F1 mice, 4 months old, were exposed to a dose of 4 Gy helium ions (exposure rate 0.05 Gy/min).

[The comparative characteristics of the reproductive capacities of swine in 3 breeds of different immunogenetic classes].

The comparative characterization of the level of development of some reproductive qualities of sows of three breeds from five breeding herds of the southern regions of Ukraine was performed in relation to peculiarities of genotypes with respect to some genetic systems of blood groups and serum proteins. Its results favor the complex approach for predicting animal productivity on the basis of data of immunogenetic analysis.

[Effect of carbacholine and serotonin on the ATPase activity in synaptosomes of the projection and association areas of the feline cerebral cortex].

Na, K-ATPase and Mg-ATPase activities were measured in the synaptosomes of the temporal auditory projection area and the frontal association area. Moreover, the effects of carbacholine and serotonin on those activities were investigated. Na, K-ATPase activity in the synaptosomes of the association area was shown to be reliably higher that in the synaptosomes of the projection area (11.

[Reconstructive treatment of patients after radical surgery of gastric cancer].

Reconstructive treatment was given to patients radically operated on for gastric cancer in the USSR (147) and Korean People's Democratic Republic (8). At the All-Union Center for Oncology Research of the USSR Academy of Medical Sciences, complex reconstructive treatment for postresection disorders included substitution and correction whereas at the Research Institute of Oncology of Pyongyang, traditional Korean herb decoctions were administered. In patients radically operated on for gastric cancer, postresection disorders were ameliorated or subsided altogether after treatment.

[A complex of conservative rehabilitation measures in postmastectomy edema].

An effective complex of rehabilitative procedures was developed on the basis of the data on 440 tumor-free patients suffering postmastectomy edema as a result of radical treatment for primary breast cancer. The complex included pneumatic compression for edema of the arm, low-frequency electric and magnetic therapy, massage, calisthenics and drug treatment.

[Comparative frequency of chromosome aberrations in a human lymphocyte culture depending on the mode of neutron irradiation].

The study of the dose dependence of the incidence of chromosome aberrations in a human lymphocyte culture exposed at the G0 stage to pulsed neutrons of 0.7 MeV revealed no significant distinctions in the cytogenetic effect at the pulse frequency of 1 and 5 Hz, but at 100 Hz it was somewhat increased. As to the biological effectiveness, pulsed neutrons of 0.

[Dynamics of microevolutionary processes during the use of pigs of various types under conditions at an industrial complex].

Breeding of pigs in a closed herd during three generations under industrial complex conditions does not essentially increase the number of animals with homozygous genotypes of polymorphic systems of blood groups. One of the possible causes of this phenomenon is selection favourable to animals with a higher heterozygosity.

Electrophoretic mobility of erythrocytes from adeturone-pretreated rats exposed to gamma or high-energy protons.

Change in electrophoretic mobility (EM) of erythrocytes was studied 6 hours after rats were exposed to a dose range (0.5-4 Gy) of high-energy protons (9 GeV/nucleon) or gamma rays (0.660 MeV), with or without adeturone pretreatment (300 mg/kg body weight).