Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series.

Introduction: Brain and spinal cord injuries may cause very severe spasticity that occasionally may be associated with persistent fever.

Case Series: We present 14 patients with spasticity and persistent fever, treated with botulinum toxin type A. Their spasticity improved and the fever resolved within a period no greater than 48 h.

Unilateral right anterior capsulotomy for refractory major depression with comorbid obsessive-compulsive disorder.

Background: Treatment-resistant major depression (MDD) and obsessive-compulsive disorder (OCD) remain a major cause of suffering and disability. These disorders may be treated with functional neurosurgery that almost always is bilateral but some patients might benefit from unilateral procedures.

Methods: We performed a unilateral right anterior capsulotomy (AC) in a 45-year-old right-handed woman with MDD and comorbid OCD.