BRCA1 and TP53 codeficiency causes a PARP inhibitor-sensitive erythroproliferative neoplasm.

Mutations in the BRCA1 tumor suppressor gene, such as 5382insC (BRCA1insC), give carriers an increased risk for breast, ovarian, prostate, and pancreatic cancers. We have previously reported that, in mice, Brca1 deficiency in the hematopoietic system leads to pancytopenia and, as a result, early lethality. We explored the cellular consequences of Brca1-null and BRCA1insC alleles in combination with Trp53 deficiency in the murine hematopoietic system.

Deficiency of the Endocytic Protein Hip1 Leads to Decreased Expression, Low Phosphocholine, and Kypholordosis.

Deficiency of huntingtin-interacting protein 1 (Hip1) results in degenerative phenotypes. Here we generated a deficiency allele where a floxed transcriptional stop cassette and a human cDNA were knocked into intron 1 of the mouse locus. -mediated germ line excision of the stop cassette resulted in expression of HIP1 and rescue of the knockout phenotype.

Pediatric asthma treatment: What to do when international guideline recommendations do not agree.

Background: There was a need for a solid asthma guideline in Mexico to update and unify asthma management. Because high-quality asthma guidelines exist worldwide, in which the latest evidence on asthma management is summarized, the ADAPTE approach allows for the development of a national asthma guideline based on evidence from already existing guidelines, adapted to national needs.

Objective: To fuse evidence from the best asthma guidelines and adapt it to local needs with the ADAPTE approach.

Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons.

Disruptions in lipid homeostasis have been observed in many neurodevelopmental disorders that are associated with dendrite morphogenesis defects. However, the molecular mechanisms of how lipid homeostasis affects dendrite morphogenesis are unclear. We find that easily shocked (eas), which encodes a kinase with a critical role in phospholipid phosphatidylethanolamine (PE) synthesis, and two other enzymes in this synthesis pathway are required cell autonomously in sensory neurons for dendrite growth and stability.

[Mexican Asthma Guidelines: GUIMA 2017].

Background: The need for a national guideline, with a broad basis among specialists and primary care physicians was felt in Mexico, to try unifying asthma management. As several high-quality asthma guidelines exist worldwide, it was decided to select the best three for transculturation.

Methods: Following the internationally recommended methodology for guideline transculturation, ADAPTE, a literature search for asthma guidelines, published 1-1-2007 through 31-12-2015 was conducted.

Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice.

The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative stress-related outcomes. We show that stress disrupts the homeostatic relationship between the microbiota and the host, resulting in exaggerated inflammation.

[Guidelines for complementary feeding in healthy infants].

A proper nutrition during the first two years of life is critical to reach the full potential of every human being; now, this period is recognized as a critical window for promoting optimal growth, development, and good health. Therefore, adequate feeding at this stage of life has an impact on health, nutritional status, growth and development of children; not only in the short term, but in the medium and long term. This paper provides recommendations on complementary feeding (CF) presented as questions or statements that are important for those who take care for children during this stage of life.

[Risk factors related to allergic diseases at Mexico City].

Background: Several studies suggest that the prevalence of allergic diseases has been increasing worldwide in recent years; then it is very important to identify some risk factors that could be related.

Objective: To know some hereditary and environmental risk factors that could be related to the development of allergic diseases in open population from Mexico City.

Patients And Method: It was an open-population, cross-sectional trial, in two phases with a random sample size of 4272 individuals in 214 public health centers.

Identification of influenza, parainfluenza, adenovirus and respiratory syncytial virus during rhinopharyngitis in a group of Mexican children with asthma and wheezing.

Background: Viral infections can promote allergic sensitization in genetically susceptible individuals. Besides, they are the main cause of wheezing in children.

Objective: To assess the frequency with which influenza, parainfluenza, adenovirus and respiratory syncytial virus (RSV) cause rhinopharyngitis in patients with asthma and wheezing.

[Prevalence of allergic diseases in Mexico City].

Background: There is a considerable variation in the prevalence of allergic disorders in developing countries. These differences may be attributable to different methodological problems and to the lack of operational definitions. Several studies suggest that the prevalence of allergic diseases has been increasing worldwide in recent years.

[Efficiency of mequitazine in the treatment of allergic rhinitis and chronic urticaria in children. A bibliographic systematic review].

Background: Allergic rhinitis, conjunctivitis and urticaria are very frequent diseases during childhood and adult age. Second generation H1 antihistamine drugs are considered first-line treatment due to their efficacy and safety.

Objective: To assess the efficacy and adverse effects of mequitazine in the treatment of these diseases.

[Allergic disease with IgE hypersynthesis. Proposal of a new denomination for an allergic disease confused with immunodeficiency].

Within the variety of diseases in which there is an excessive production of immunoglobulin E (IgE), clinicians have the dilemma to establish a differential diagnosis between allergy, immunodeficiency and even autoimmunity. In the present study the clinical manifestations of allergic patients who presented very high levels of IgE and who were taken care of in the Allergy Service of the National Institute of Pediatrics and did not show criteria to be identified as carriers of some non-atopic immunological disease (eg. Hyper-IgE syndrome), are described.

[Indications for sunflower oil concentrate in the treatment of atopic dermatitis].

The treatment of atopic dermatitis, as other diseases that present a sensible skin, includes a series of therapeutic measures initiating with the general cares of the skin and application of elements that allow to preserve the functionality through relipidization and the inhibition of some components of the inflammation. This article includes a series of concepts that justify the use of sunflower oil concentrated like a weapon of forward edge in the treatment of these morbidities.

[Hypoacusis in pediatric patients with allergic rhinitis].

Currently, allergic disorders represent an important problem of public health. Besides having high prevalence they begin their clinical manifestations at early ages, in 75% of the cases before five years old. When they do not receive the proper treatment, they have systemic affectation, with a repercussion in the quality of life.

[Efficacy and safety of astemizole in the treatment of allergic rhinitis and urticaria: a systematic review with meta-analysis].

Objective: To compare astemizole with other first or second generation antihistaminics in the treatment of allergic rhinitis or urticaria.

Design: Systematic revision of clinical, controlled and randomized tests.

Material And Methods: 36 controlled, randomized, clinical, double or simple blind tests were made in 6,446 patients; 4,513 of them were assigned to astemizole and 1,933 to other first or second generation antihistaminics.

[Relation between Helicobacter pylori and atopic diseases].

The rise in the incidence of atopic diseases in the last years is associated to a greater prevalence of viral and bacterial infections. The infections facilitate a chronic inflammatory process that is directly related to the sensibilization of mast cells which favors manifestations of allergic diseases. Within the proposed bacteriological agents as causes of is Helicobacter pylori.

[Allergens and risk factors in pediatric patients with allergic seasonal conjunctivitis].

Background: The seasonal allergic conjunctivitis is an inflammatory disease of the ocular surface that affects mainly children, with predominance of male sex. It is an immunological disease with a typical reaction of hypersensitivity type 1 (IgE), resulted from several biological reactions (antigen-antibody) and it's associated to several risk factors.

Objective: To determine the more frequently identified allergens and the associated risk factors to the seasonal allergic conjunctivitis in children living in Mexico City.