Data of the effects of acetone fraction from (Jacq.) S.w. edible roots in the kidney of endothelial dysfunction induced mice.

Endothelial dysfunction induced by Angiotensin II (AG II) plays an important role in the pathogenesis of hypertension and is accompanied by a prooxidative condition, which in turn induces an inflammatory state, vascular remodeling, and tissue damage including the kidney (Schmitt and Dirsch, 2009) [1]. New drugs that can control several of these pathologies are required. has been reported to possess antioxidant, anti-inflammatory and antihypertensive activity (Ibarra-Alvarado et al.

Acetone fraction from Sechium edule (Jacq.) S.w. edible roots exhibits anti-endothelial dysfunction activity.

Ethnopharmacological Relevance: A recent ethnomedical survey on medicinal plants grown in Mexico revealed that Sechium edule (Jacq.) Sw. (Cucurbitaceae) is one of the most valued plant species to treat cardiovascular diseases, including hypertension.

S-Adenosyl-L-methionine increases serum BUN and creatinine in cisplatin-treated mice.

Cisplatin is an effective antineoplastic agent in the treatment of various solid tumors, although its full clinical utility is limited because of its renal toxicity. Several measures to protect the kidneys from cisplatin toxicity have been investigated and implemented in clinical trials; however, none of these were completely effective or without secondary effects. The aim of this study was to investigate S-adenosyl-L-methionine (SAM) as an agent that protects against cisplatin nephrotoxicity without affecting the antineoplastic activity of cisplatin.

Effects of mesocaval shunt on the pharmacokinetics of metronidazole in young rats.

Prophylactic and therapeutic management of portosystemic encephalopathies is based on protein restriction in the diet, and the use of lactulose and antibiotics such as metronidazole. These actions intend to reduce the main source of intestinal ammonia production and release into the systemic circulation. The aim of this study was to evaluate the medium-term effects of mesocaval shunt on the pharmacokinetics of metronidazole in rats with healthy livers.

Collagen-PVP, a collagen synthesis modulator, decreases intraperitoneal adhesions.

Background: Adhesion formation in the peritoneal cavity is the most common cause of intestinal obstruction and secondary female infertility. A great effort has been dedicated to reduce adhesion formation because of the associated morbidity and its complications.

Materials And Methods: This study was designed as a before-after comparative trial and included 14 rabbits, with a weight between 300 and 500 g.