Publications by authors named "Gerard-Menan Kouame"
Article Synopsis
- Gay, bisexual, and other men who have sex with men (MSM) in Africa face significant barriers to HIV prevention and treatment, which contributes to their higher rates of HIV infection.
- A systematic review of studies from 1980 to 2023 found that while HIV testing among MSM has increased, with 73% having ever tested by 2020, only half were aware of their HIV status.
- Current use of antiretroviral therapy (ART) has improved, with 73% of MSM living with HIV on ART, but viral suppression rates remain low at 69%, and no significant decrease in HIV incidence was observed.
Objectives: We report the association between pre-antiretroviral therapy (pre-ART) soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and long-term mortality in HIV-infected West African adults participating in a trial of early ART in West Africa (Temprano ANRS 12136 trial).
Methods: The ART-naïve HIV-infected adults were randomly assigned to start ART immediately or defer ART until the WHO criteria were met. Participants who completed the trial follow-up were invited to participate in a post-trial phase (PTP).
It is unknown how past and active hepatitis B virus (HBV) infection affect immunorecovery and mortality in people with HIV who initiate tenofovir-based antiretroviral therapy (ART). Using data collected between 2008 and 2015, we studied people with HIV in sub-Saharan Africa initiating immediate ART in the Temprano randomized control trial. We classified participants into HBV groups at ART initiation: hepatitis B surface antigen (HBsAg)-positive with HBV DNA ≥ 2,000 IU/ml; HBsAg-positive with HBV DNA < 2,000 IU/ml; isolated HBcAb-positive; resolved infection (HBsAb-positive/HBcAb-positive); and HBV non-immune/vaccinated (HBcAb-negative).
View Article and Find Full Text PDFWe here report the case of a 35-year old man with HIV-1 but with no previous medical-surgical history hospitalized in Abidjan, Côte d'Ivoire, due to fever, cough, dyspnea, chest pain and unfolding of the aortic arch observed on chest x-ray a week after having started antiretroviral therapy (ART). CT angiography of the thoracic aorta showed overall, extended aortic ectasia with mural thrombus. Transesophageal echocardiography objectified type A ascending aortic dissection (Stanford classification).
View Article and Find Full Text PDFBackground: In human immunodeficiency virus (HIV)-infected patients, hepatitis B virus (HBV) coinfection increases the risk of disease progression. Tenofovir plus emtricitabine/lamivudine (TDF/XTC)-based antiretroviral therapy (ART), which suppresses HIV and HBV replication, has the potential for decreasing this risk. Here, we analyze the association between HBV replication, early ART, and mortality in West African adults.
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- * The study included 2,056 participants, mostly women with an average age of 35, finding strong correlation between CVR scores estimated by BMI and lipids, and observed a slight increase in high CV risk scores over time, especially among women.
- * Despite the observed increase in risk scores, early initiation of antiretroviral treatment (ART) did not significantly influence CVR score changes, indicating that other factors may play a larger role in cardiovascular risk among this population.
Based on social indicators collected within the TEMPRANO-ANRS12136 trial, we assessed the social consequences of early antiretroviral therapy (ART) initiation in west Africa. We did not observe any significant differences in the levels or the time trends of various social indicators, including union status, HIV disclosure and HIV-related discrimination, between early and deferred ART initiation. Early ART does not carry detectable adverse social consequences that could impair its clinical and preventive benefits.
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