Human papillomavirus 16 is an aetiological factor of scrotal cancer.

Background: Squamous cell scrotal carcinoma (SCSC) is an infrequent skin cancer associated historically with occupational carcinogens. Human papillomavirus (HPV) DNA has been associated with SCSC but there is no definitive proof of its oncogenic role.

Methods: Human papillomavirus-DNA and -E6*I mRNA were analysed in six invasive histologically typed SCSC.