Publications by authors named "Gerard J Sonico"
Brain changes at the end-stage of fragile X-associated tremor/ataxia syndrome (FXTAS) are largely unknown due to mobility impairment. We conducted a postmortem MRI study of FXTAS to quantify cerebrovascular disease, brain atrophy and iron content, and examined their relationships using principal component analysis (PCA). Intracranial hemorrhage (ICH) was observed in 4/17 FXTAS cases, among which one was confirmed by histologic staining.
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- Scientists studied how the brains of people with fragile X-associated tremor/ataxia syndrome (FXTAS) change after they passed away because they can’t move well due to the illness.
- They found that FXTAS brains had more serious problems like bleeding and shrinking areas in certain parts of the brain compared to healthy brains.
- The research showed that FXTAS can cause damage in different ways, like losing the brain's protective covering and extra iron build-up, which can make it harder for the brain to work properly.