An easy maneuver to screen for moderate-to-severe obstructive sleep spnea: the Simmons Chin Press and Tongue Curl.

Objectives: To demonstrate that the Simmons chin press and tongue curl (SCPTC) correlates with diagnosis of moderate-to-severe obstructive sleep apnea (msOSA) by itself as well as irrespective of the presence of other associated features.

Material And Methods: A consecutive sample of 1,911 sleep studies performed on adult patients from 2/8/2017 to 3/5/2019 was analyzed. The SCPTC exam maneuver was performed on each patient, followed by home sleep apnea testing or in-laboratory polysomnography.

Clinical Impact of Pitolisant on Excessive Daytime Sleepiness and Cataplexy in Adults With Narcolepsy: An Analysis of Randomized Placebo-Controlled Trials.

Background: Pitolisant, a selective histamine 3 receptor antagonist/inverse agonist, is indicated for the treatment of excessive daytime sleepiness or cataplexy in adults with narcolepsy. The efficacy and safety of pitolisant have been demonstrated in randomized placebo-controlled trials. When evaluating the results of randomized placebo-controlled trials, the clinical impact of a treatment can be assessed using effect size metrics that include Cohen's d (the standardized mean difference of an effect) and number needed to treat (NNT; number of patients that need to be treated to achieve a specific outcome for one person).