Publications by authors named "Gerard Acloque"
Toll-like receptor-driven and interleukin-1 (IL-1) receptor-driven inflammation mediated by IL-1 receptor-associated kinase 4 (IRAK4) is involved in the pathophysiology of hidradenitis suppurativa (HS) and atopic dermatitis (AD). KT-474 (SAR444656), an IRAK4 degrader, was studied in a randomized, double-blind, placebo-controlled phase 1 trial where the primary objective was safety and tolerability. Secondary objectives included pharmacokinetics, pharmacodynamics and clinical activity in patients with moderate to severe HS and in patients with moderate to severe AD.
View Article and Find Full Text PDFBackground: Five hundred milligrams of intravenous (IV) sotrovimab has been shown to be well tolerated and efficacious against pre-Omicron strains in treating patients with mild to moderate coronavirus disease 2019 (COVID-19) at high risk for disease progression.
Methods: This was an open-label, single-arm substudy of phase 3 COMET-TAIL (NCT04913675) assessing the safety and tolerability of a 2000 mg IV dose of sotrovimab. Symptomatic patients (aged ≥18 years) with COVID-19 at high risk for progression were enrolled from June 30 through July 11, 2022, when Omicron BA.
Article Synopsis
- In the REGEN-COV adaptive trial, a combination of monoclonal antibodies significantly reduced both viral load and hospital visits in COVID-19 patients compared to a placebo.
- In the phase 3 trial, outpatients with COVID-19 received either REGEN-COV or placebo, leading to a substantial decrease in hospitalization or death rates (1.3% in the 2400-mg group vs. 4.6% in placebo).
- The treatment also expedited symptom resolution by an average of 4 days and effectively reduced viral load more rapidly than the placebo across various patient subgroups.