Publications by authors named "Geralyn M Messerlian"
Study Objectives: To examine the association between maternal sleep disordered breathing (SDB) and glucose metabolism in early gestation.
Methods: Women with body mass index (BMI) ≥27 kg/m2 and singleton pregnancies underwent in-home sleep study (HSAT) and homeostatic model assessment (HOMA) in early pregnancy. Insulin resistance (HOMA-IR) and β-cell function (HOMA %B) were derived.
Article Synopsis
- The study aimed to find out if measuring plasma Müllerian inhibiting substance (MIS) can replace measuring serum MIS.
- Eighteen paired samples of serum and plasma were tested simultaneously for their MIS levels using an ELISA kit.
- A strong correlation of 98.5% was observed between plasma and serum MIS values, indicating that plasma measurements may be a reliable alternative.
Context: Previous studies suggest that inhibin subunit expression is decreased in granulosa cells of women with polycystic ovary syndrome (PCOS).
Objective: The objective of this study was to test the hypothesis that inhibin A and inhibin B protein concentrations are also decreased in PCOS follicles.
Design: The design was a parallel study.
Objective: Clinical applications of the analysis of cell-free fetal DNA in maternal plasma and serum are expanding. However, use of fetal DNA during prenatal screening requires knowledge of variables that might affect its levels in the maternal circulation. We conducted this study to estimate the effect of selected demographic factors on fetal DNA levels in the first and second trimesters of pregnancy.
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- The addition of serum markers over the past 15 years has improved the detection of pregnancies affected by Down syndrome.
- In the 1990s, screening methods were enhanced by including new biochemical markers and combining first trimester blood tests with ultrasound.
- Recent advancements in prenatal screening could enable nearly all pregnant women to avoid risky procedures like amniocentesis while achieving detection rates close to 90%.
Article Synopsis
- * Researchers examined serum samples from pregnant women carrying male fetuses with trisomy 13 and 18, comparing their fetal DNA levels to controls presumed to be healthy (euploid).
- * Results indicated significantly elevated fetal DNA levels in mothers with trisomy 13 compared to controls, while levels in trisomy 18 cases were similar to controls, suggesting a need for a gender-independent marker for broader screening.
Objective: Increased levels of cell-free fetal DNA (f-DNA) in the maternal circulation are a potential noninvasive marker for fetal Down syndrome. Our objectives were to (1) determine whether f-DNA could be quantified by using archived serum and amniotic fluid, (2) examine whether serum f-DNA levels are elevated in Down syndrome pregnancies in a case-control series matched for gestational age and duration of sample storage, and (3) determine whether f-DNA levels are elevated in the amniotic fluid of Down syndrome fetuses.
Study Design: Eleven serum and six amniotic fluid samples previously collected and stored at -20 degrees C from gravid women carrying a 47,XY,+21 fetus were each paired with five matched control samples of identical specimen type from gravid women carrying a presumed euploid male fetus.