Reduction in ventilator-induced lung injury improves outcome in congenital diaphragmatic hernia?

The purpose of this historical study was to compare the outcome for two treatment strategies, for neonates with congenital diaphragmatic hernia (CDH). The records of 65 infants born between 1991 and 2005 with CDH from a single tertiary care perinatal centre in the United Kingdom were retrospectively reviewed. Conventional mechanical ventilation (CMV) and systemic vasodilators were used from 1991 to 1995 (era 1).

Aminophylline as an adjunct diuretic for neonates--a case series.

Aminophylline is an adenosine receptor antagonist. Adult and paediatric studies have demonstrated a diuretic effect of aminophylline due to increased renal blood flow and the inhibition of solute reabsorption in various segments of the nephron. We report a case series of five infants with volume overload despite frusemide treatment.

Cardiovascular collapse after amiodarone administration in neonatal supraventicular tachycardia.

Amiodarone is recommended by the International Liaison Committee on Resuscitation and has been adapted by the Resuscitation Council (UK) and the Advanced Life Support Group for use in paediatric advanced life support and advanced paediatric life support for the treatment of refractory supraventricular tachycardia. The International Liaison Committee on Resuscitation has stated that resuscitation guidelines should be evidence based. We present a case report of a cardiovascularly stable infant with supraventricular tachycardia who had a variety of arrthymias requiring cardiopulmonary resucitation for a prolonged period of time after loading with intravenous amiodarone.

Discrepancies between ordered and delivered concentrations of opiate infusions in critical care.

Objectives: We sought to test the assumption that the measured concentrations of medication infusions are within pharmaceutical standards (+/-10% of intended concentrations) and whether, at the time the infusion was mixed, the professional background of persons preparing the infusion or the unit for which the infusion was prepared were related to the observed variation.

Design, Setting, And Participants: This prospective, observational study was conducted in the neonatal and pediatric intensive care units of a university-affiliated tertiary pediatric center. Morphine infusions prepared for clinical use were randomly sampled over a 7-month period.