Publications by authors named "Geraldine S Ramon"
Article Synopsis
- * Researchers are exploring ways to reprogram these TAMs into a pro-inflammatory (M1) state with anti-tumoral effects by using engineered vesicles derived from macrophages.
- * Studies show that vesicles from the endoplasmic reticulum (erMEVs) are more effective than those from the plasma membrane (pmMEVs) in boosting pro-inflammatory responses and fighting cancer cells, highlighting the importance of their origin in therapy design.
Tumor-associated macrophages are the predominant immune cells present in the tumor microenvironment and mostly exhibit a pro-tumoral M2-like phenotype. However, macrophage biology is reversible allowing them to acquire an anti-tumoral M1-like phenotype in response to external stimuli. A potential therapeutic strategy for treating cancer may be achieved by modulating macrophages from an M2 to an M1-like phenotype with the tumor microenvironment.
View Article and Find Full Text PDFCongenital long QT syndrome (LQTS) is characterized by a prolonged QT-interval on an electrocardiogram (ECG). An abnormal prolongation in the QT-interval increases the risk for fatal arrhythmias. Genetic variants in several different cardiac ion channel genes, including KCNH2, are known to cause LQTS.
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