Changes in social behavior with MAPK2 and KCTD13/CUL3 pathways alterations in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders.

Copy number variations (CNVs) of the human 16p11.2 locus are associated with several developmental/neurocognitive syndromes. Particularly, deletion and duplication of this genetic interval are found in patients with autism spectrum disorders, intellectual disability and other psychiatric traits.

Computing Odor Images.

This perspective examines psychophysical methods that may reveal the algorithms that encode odor images by integrating current data from sensory measurement into a computational model of odor perception. There is evidence that algorithms used by the nervous system to process odor sensations require input from only a few odorants, between three and eight. Furthermore, the number of recognizable odors in foods that contribute anything to the aroma of all foods is approximately 250.

A suppressor locus for MODY3-diabetes.

Maturity Onset Diabetes of the Young type 3 (MODY3), linked to mutations in the transcription factor HNF1A, is the most prevalent form of monogenic diabetes mellitus. HNF1alpha-deficiency leads to defective insulin secretion via a molecular mechanism that is still not completely understood. Moreover, in MODY3 patients the severity of insulin secretion can be extremely variable even in the same kindred, indicating that modifier genes may control the onset of the disease.