Publications by authors named "Geraldine Pina"
Article Synopsis
- The study evaluates a new second-generation assay for measuring basal serum calcitonin (CT) in diagnosing and monitoring medullary thyroid carcinoma (MTC), suggesting it may be a viable alternative to the pentagastrin-stimulation test.
- A total of 162 patients, including those with RET proto-oncogene mutations and postoperative follow-up cases, participated, with measurements taken for both basal and Pg-stimulated CT levels.
- Results showed that while the new assay has high specificity and reduces false negatives compared to older methods, its sensitivity for detecting C-cell disease is still lower than that provided by the Pg-stimulation test.
Melatonin, which shows a robust nycthemeral rhythm, plays the role of an endogenous synchronizer, able to stabilize and reinforce circadian rhythms and maintain their mutual phase relationships. Additionally, melatonin is a potent antioxidant and displays immunological properties. Because free radical generation, immune dysfunction, and sleep and metabolic disorders are involved in the short- and long-term pathophysiology of the burn syndrome, we undertook the study of daily urine melatonin, 6-sulfatoxymelatonin (aMT6s, the main hepatic melatonin metabolite), and cortisol variations plus temperature profiles in burn patients using a non-invasive protocol.
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