Costs associated with implementation of a strict policy for controlling spread of highly resistant microorganisms in France.

Objective: To assess costs associated with implementation of a strict 'search and isolate' strategy for controlling highly drug-resistant organisms (HDRO).

Design: Review of data from 2-year prospective surveillance (01/2012 to 12/2013) of HDRO.

Setting: Three university hospitals located in northern Paris.

Diversity of individual dynamic patterns of emergence of resistance to quinolones in Escherichia coli from the fecal flora of healthy volunteers exposed to ciprofloxacin.

Background: Emergence of quinolone-resistant Escherichia coli (QREC) is an increasing clinical challenge mostly originating in fecal microbiota. The dynamics of the emergence of QREC in feces from individuals exposed to ciprofloxacin is unknown.

Methods: A total of 48 healthy volunteers received oral ciprofloxacin for 14 days.

Replicon typing of plasmids in Escherichia coli producing extended-spectrum beta-lactamases.

Objectives: Escherichia coli producing CTX-M-15 and CTX-M-14 extended-spectrum beta-lactamases (ESBLs) are spreading worldwide. The aim of this work was to investigate the replicons involved in the emergence and spread of ESBLs in relation to ESBL type.

Methods: A collection of 125 TEM, SHV and CTX-M ESBL-producing E.