The impact of whey protein preheating on the properties of emulsion gel bead.

Thermal treatment effect (70 or 80 °C for 5 or 30 min) was evaluated on functional properties of whey protein isolate (WPI) dispersions used for the development of novel vitamin A delivery systems based on emulsion gel beads. This process combines an (O/W) emulsion diluted by a polysaccharide solution and a cold-set gelation induced by salt addition. Pre-heated WPI had a significant impact on the denaturation degree and on the surface hydrophobicity, respectively studied by differential scanning calorimetry and fluorescence.

Effect of pH on the association behavior in aqueous solutions of pig gastric mucin.

In this study, dynamic light scattering (DLS), turbidity, and rheo-small angle light scattering (rheo-SALS) methods have been utilized to examine the impact of pH (1 < or = pH < or = 7) on aqueous solutions of noncommercial purified pig gastric mucin. The asymmetric flow field-flow fractionation (AFFFF) measurements established that the mucin sample has a high molecular weight and is polydisperse. DLS measurements on dilute solutions of mucin disclosed large interchain aggregates at pH 2, where the polymer has a low charge density or is uncharged.

Diffusion of nutrients molecules and model drug carriers through mucin layer investigated by magnetic resonance imaging with chemical shift resolution.

Magnetic resonance imaging (MRI) with chemical shift resolution is a recent extension of MRI and it provides information about species resolved molecular transport on the macroscopic scale in complex systems. In this contribution, we show that by using this novel method, one can predict the behavior of drug and food molecules when they are in contact with the mucosal layer in the gastrointestinal tract. For the first time, the transport properties of a mixture of nutrients (i.

Mixtures of mucin and oppositely charged surfactant aggregates with varying charge density. Phase behavior, association, and dynamics.

The nonionic surfactant Tween80 is a commonly used excipient in drug formulations containing an active substance with low aqueous solubility. Model drug vehicles with varying charge density were obtained by mixing Tween80 (PS-80) with the cationic surfactant Tetradecyltrimethylammonium chloride (TTAC), thus forming mixed micelles. The micelles were mixed with the negatively charged polyelectrolyte mucin, which is a component in the protective mucus layer covering epithelial cell linings.