Influence of chronic phenytoin administration on the pharmacokinetics and pharmacodynamics of vecuronium.

Background: The duration of action of vecuronium is reduced in patients receiving phenytoin. In this study, the authors examined, simultaneously, the influence of phenytoin on both the pharmacokinetics and the pharmacodynamics of vecuronium.

Methods: This study was approved by the institutional review board of the University of California, San Francisco, and patients gave written informed consent.