Case-control study of the effects of trihalomethanes on urinary bladder cancer risk.

In this research, the authors examined the relation between the estimated concentrations in drinking water of disinfectant byproduct (DBP) trihalomethanes (THMs) and the risk for urinary bladder cancer in a case-control study of 567 white men aged 35 to 90 years, in western New York State. They used logistic regression to estimate odds ratios (ORS) and to assess the effects of THM consumption on cancer risk. Higher levels of consumption of THMs led to increased risk for cancer of the urinary bladder (total 551, a composite measure of THMs based upon method 551 developed by the US Environmental Protection Agency: OR = 2.

Case control study of the geographic variability of exposure to disinfectant byproducts and risk for rectal cancer.

Background: Levels of byproducts that result from the disinfection of drinking water vary within a water distribution system. This prompted us to question whether the risk for rectal cancer also varies, depending upon one's long term geographic location within the system. Such a geographic distribution in rectal cancer risk would follow naturally from an association between level of byproduct and rectal cancer risk.