Ependymal cell lineage reprogramming as a potential therapeutic intervention for hydrocephalus.

Hydrocephalus is a common neurological condition, characterized by the excessive accumulation of cerebrospinal fluid in the cerebral ventricles. Primary treatments for hydrocephalus mainly involve neurosurgical cerebrospinal fluid diversion, which hold high morbidity and failure rates, highlighting the necessity for the discovery of novel therapeutic approaches. Although the pathophysiology of hydrocephalus is highly multifactorial, impaired function of the brain ependymal cells plays a fundamental role in hydrocephalus.

Exploring a unified description of the super-Arrhenius region above and below the glass transition temperature.

A new approach is presented in order to check whether the hypothesis of an Arrhenius component surviving in the α-relaxation region is consistent with experimental data. The temperature dependence of the dynamics in the whole glassy regime is described by an equation which assumes an Arrhenius component in the cooperative diffusion. Based on thermodynamic arguments, the dynamic heterogeneities close to the glass transition region are related to structural heterogeneities in a manner consistent with the idea of a sigmoidal shape in the cohesion energy.

A microscopic view of graphene-oxide/poly(acrylic acid) physical hydrogels: effects of polymer charge and graphene oxide loading.

In this work we have examined in detail by means of fully atomistic molecular dynamics simulations, physical hydrogels formed by a polymer electrolyte, poly(acrylic acid), and graphene oxide, at two different charging states of the polymer and two different graphene oxide concentrations. It was found that variations of these parameters incurred drastic changes in general morphological characteristics of the composite materials, the degree of physical adsorption of polyelectrolyte chains onto the graphene oxide surface, the polymer dynamic response at local and global length scales, in the charge distributions around the components, and in the mobility of the counterions. All these microscopic features are expected to significantly affect macroscopic physical properties of the hydrogels, such as their mechanical responses and their electrical behaviors.