Publications by authors named "Georgios Kremastiotis"
Matrix metalloproteinase (MMP) activity is tightly regulated by the endogenous tissue inhibitors (TIMPs), and dysregulated activity contributes to extracellular matrix remodelling. Accordingly, MMP/TIMP balance is associated with atherosclerotic plaque progression and instability, alongside adverse post-infarction cardiac fibrosis and subsequent heart failure. Here, we demonstrate that prolonged high-fat feeding of apolipoprotein (Apo)e-deficient mice triggered the development of unstable coronary artery atherosclerosis alongside evidence of myocardial infarction and progressive sudden death.
View Article and Find Full Text PDFArticle Synopsis
- Carfilzomib (Cfz) is a proteasome inhibitor used for treating myeloma but causes heart damage; the study aimed to determine how it impacts cardiac function and how metformin (Met) might protect against this damage.
- Various protocols were tested on mice, where Cfz was given in different regimens, showing that Cfz impaired heart function in most cases but not when given intermittently (protocols 5A and 5B).
- Molecular analysis revealed that Cfz disrupts key signaling pathways in heart cells, but the addition of Met successfully prevented heart function decline and restored important molecular signals, suggesting Met could help mitigate Cfz's harmful effects on the heart.