Publications by authors named "Georgios Gkortzolidis"
Article Synopsis
- Modern treatments for blood cancers have greatly enhanced patient outcomes, but many cancer drugs can lead to serious heart-related issues.
- Understanding these potential cardiovascular complications, such as heart failure and rhythm disturbances, is essential for optimal patient care.
- The review highlights the symptoms, prevention strategies, and management of heart toxicity in patients receiving cancer treatments or stem cell transplants.
In this phase 1/2 study, we explored the feasibility and activity of an oral regimen of lenalidomide with low-dose dexamethasone and low-dose oral cyclophosphamide (RdC) in patients with primary systemic light chain amyloidosis. RdC was given for up to 12 cycles in prespecified cohorts at escalated doses: 13 patients were treated in phase 1 and 24 in phase 2; 65% were previously untreated, and most had renal and/or cardiac involvement and elevated cardiac biomarkers. Lenalidomide 15 mg/d and cyclophosphamide 100 mg/d were further evaluated in phase 2.
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