Rapid magnetic heating treatment by highly charged maghemite nanoparticles on Wistar rats exocranial glioma tumors at microliter volume.

One of the most significant challenges implementing colloidal magnetic nanoparticles in medicine is the efficient heating of microliter quantities by applying a low frequency alternating magnetic field. The ultimate goal is to accomplish nonsurgically the treatment of millimeter size tumors. Here, we demonstrate the synthesis, characterization, and the in vitro as well as in vivo efficiency of a dextran coated maghemite (gamma-Fe(2)O(3)) ferrofluid with an exceptional response to magnetic heating.

Laparoscopic transabdominal preperitoneal hernia repair (TAPP): stapling the mesh is not mandatory.

Background: This report reviews our experience with 104 transabdominal preperitoneal (TAPP) hernia repairs, using a selective staple-free technique, over the period April 2003 to July 2007 (50 months).

Materials And Methods: Ninety-one patients underwent TAPP repair (13 bilateral). Eighty-one were males and 10 females.

Is inflammation a significant predictor of bile duct injury during laparoscopic cholecystectomy?

Background: Bile duct injuries (BDI) have been reported to occur more frequently during laparoscopic cholecystectomy (LC) compared to open cholecystectomy (OC). Several studies have demonstrated various potential predisposing factors for BDI. However, there is a controversy as to whether gallbladder inflammation is a significant predictor for BDI.

CLIP-170/tubulin-curved oligomers coassemble at microtubule ends and promote rescues.

Background: CLIP-170 is a microtubule binding protein specifically located at microtubule plus ends, where it modulates their dynamic properties and their interactions with intracellular organelles. The mechanism by which CLIP-170 is targeted to microtubule ends remains unclear today, as well as its precise effect on microtubule dynamics.

Results: We used the N-terminal part of CLIP-170 (named H2), which contains the microtubule binding domains, to investigate how it modulates in vitro microtubule dynamics and structure.